Evidence map›Paper›PMID 18651176›Full record

ArticleEuropean journal of pediatrics2008

Cytomegalovirus-associated protein-losing gastropathy in childhood.

O Megged, Y Schlesinger

Abstract readCase Reports
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In one paragraph

Article in European journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Current research in microbial sciences · 2026
    Article
  2. Pediatric Ménétrier's Disease Triggered byCase reports in pediatrics · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Diagnosis and Management of Ménétrier Disease in Children: A Case Series Review.Pediatric gastroenterology, hepatology & nutrition · 2021
    Article
  9. Article
  10. An Unusual Presentation of Cytomegalovirus Infection: Generalized Edema.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020
    Article
  11. Menetrier's disease (protein-losing gastropathy) in a child with acute lymphoblastic leukemia.International journal of pediatrics & adolescent medicine · 2019
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

O MeggedDepartment of Pediatrics and Infectious Diseases Unit, Shaare Zedek Medical Center, Hadassah-Hebrew University Medical School, Jerusalem, Israel. orlimegged@yahoo.com
Y Schlesinger

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Menetrier's disease is an uncommon disease in childhood, characterized by gastric hypertrophy and hypoalbuminemia secondary to protein loss through the gastric mucosa. This paper describes a series report of protein-losing gastropathy associated with cytomegalovirus (CMV) infection in children and reviews the literature. We reviewed the medical records of eight children with diagnosis of Menetrier's disease or protein-losing gastropathy with evidence of acute CMV infection. During a five-year period there were eight children that were diagnosed with CMV-associated protein-losing gastropathy, all in one medium-sized pediatric ward in a general hospital. The mean age was 32 months and there was no gender predominance. The most common presenting symptoms were vomiting and edema. Average symptoms' duration prior to admission was 3.2 weeks and mean albumin at presentation was 1.8 g/dl (range, 1.5-2.5 g/dl; normal values, 3.5-5 g/dl). All eight children fully recovered. In conclusion, CMV infection should be suspected in every child who presents with protein-losing gastropathy. The availability of newer, rapid diagnostic techniques such as polymerase chain reaction (PCR) may facilitate diagnosis, as serology studies may be misleading. Usually, only supportive care is required, but treatment with ganciclovir may be considered for severe or prolonged cases.

Indexed as

ChildChild, PreschoolCytomegalovirus InfectionsFemaleGastric MucosaGastritis, HypertrophicHumansHypertrophyHypoalbuminemiaImmunoglobulin MInfantMaleProtein-Losing EnteropathiesSeverity of Illness IndexStomachTumor Necrosis Factor-alphaImmunoglobulin MTumor Necrosis Factor-alpha

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.