ArticleThe EMBO journal2008
A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 87 citations in OpenAlex.
- The superpowers of imprinting control regions.Genome research · 2026Review
- Mom genes and dad genes: genomic imprinting in the regulation of social behaviors.Epigenomics · 2025Review
- Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states.Nucleic acids research · 2025Article
- Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells.Nucleic acids research · 2025Article
- Allelic reprogramming of chromatin states in human early embryos.National science review · 2024Article
- Inheritance of paternal lifestyles and exposures through sperm DNA methylation.Nature reviews. Urology · 2023Review
- Histone modifications and DNA methylation act cooperatively in regulating symbiosis genes in the sea anemone Aiptasia.BMC biology · 2022Article
- Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.Molecular cell · 2022Article
- Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions.Cell reports · 2022Article
- Variable allelic expression of imprinted genes at theFrontiers in cell and developmental biology · 2022Article
- Article
- Imprinted Genes and Multiple Sclerosis: What Do We Know?International journal of molecular sciences · 2021Review
- TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.Cellular and molecular life sciences : CMLS · 2021Article
- Review
- Revealing eukaryotic histone-modifying mechanisms through bacterial infection.Seminars in immunopathology · 2020Review
- Role of genomic imprinting in mammalian development.Journal of biosciences · 2020Review
- Review
- Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.Genome biology · 2019Article
- Primed histone demethylation regulates shoot regenerative competency.Nature communications · 2019Article
- Three classes of response elements for human PRC2 and MLL1/2-Trithorax complexes.Nucleic acids research · 2018Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Genomic imprinting is a developmental mechanism that mediates parent-of-origin-specific expression in a subset of genes. How the tissue specificity of imprinted gene expression is controlled remains poorly understood. As a model to address this question, we studied Grb10, a gene that displays brain-specific expression from the paternal chromosome. Here, we show in the mouse that the paternal promoter region is marked by allelic bivalent chromatin enriched in both H3K4me2 and H3K27me3, from early embryonic stages onwards. This is maintained in all somatic tissues, but brain. The bivalent domain is resolved upon neural commitment, during the developmental window in which paternal expression is activated. Our data indicate that bivalent chromatin, in combination with neuronal factors, controls the paternal expression of Grb10 in brain. This finding highlights a novel mechanism to control tissue-specific imprinting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.