ArticleThe EMBO journal2008
Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers.
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Who cites it
226 citing papers in PubMed, 500 citations in OpenAlex.
- SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling.Plant physiology · 2026Article
- AtHSPR Plays a Positive Role in Arabidopsis Resistance AgainstBiomolecules · 2026Article
- The Transcription Factor OsWRKY30 Regulates Rice Resistance to Southern Rice Black Streaked Dwarf Virus Disease.Rice (New York, N.Y.) · 2026Article
- HDA6 represses the histone acetylation modification and expression of WRKY18/40 to inhibit camalexin biosynthesis in Arabidopsis.Plant cell reports · 2026Article
- MdRLKT1-MdRAX2-MdMKS1 Module Positively Regulating Resistance to Cytospora mali in Apple.Plant biotechnology journal · 2026Article
- GhLYK5-mediated GhNIT4B activates asparagine and ROS accumulation enhancing cotton Verticillium wilt resistance.Journal of biological engineering · 2026Article
- Regulatory mechanisms of amino acid metabolic pathways in Rhododendron chrysanthum Pall. Under UV-B stress.PloS one · 2026Article
- Receptor-like cytoplasmic kinases mediated signaling in plant immunity: convergence and divergence.Stress biology · 2025Review
- Phosphorylation of CPR5 by the receptor-like kinase FLR2 promotes mRNA poly(A) tail processing and immunity to Magnaporthe oryzae in rice.Plant communications · 2025Article
- ANAC042 Regulates the Biosynthesis of Conserved- and Lineage-Specific Phytoalexins in Arabidopsis.International journal of molecular sciences · 2025Article
- Molecular Insights into the Positive Role of Soybean Nodulation by GmWRKY17.International journal of molecular sciences · 2025Article
- Comparative transcriptomic analysis and genome-wide identification provide insights into the potential role of fungal-responsive MAPK cascade genes in tanshinone accumulation inFrontiers in plant science · 2025Article
- Protein elicitor PeVn1 induces resistance toFrontiers in microbiology · 2025Article
- The WRKY Family Transcription Factor GmWRKY72 Represses Glyceollin Phytoalexin Biosynthesis in Soybean.Plants (Basel, Switzerland) · 2024Article
- Arabidopsis WRKY55 Transcription Factor Enhances Soft Rot Disease Resistance with ORA59.The plant pathology journal · 2024Article
- Grapevine gray mold disease: infection, defense and management.Horticulture research · 2024Article
- Structural basis for the regulation of plant transcription factor WRKY33 by the VQ protein SIB1.Communications biology · 2024Article
- Genome-Wide Analysis of the WRKY Transcription Factor Family in Roses and Their Putative Role in Defence Signalling in the Rose-Blackspot Interaction.Plants (Basel, Switzerland) · 2024Article
- MAPK Cascades in Plant Microbiota Structure and Functioning.Journal of microbiology (Seoul, Korea) · 2024Review
- Advances in epigenetic studies of plant cadmium stress.Frontiers in plant science · 2024Review
166 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant and animal perception of microbes through pathogen surveillance proteins leads to MAP kinase signalling and the expression of defence genes. However, little is known about how plant MAP kinases regulate specific gene expression. We report that, in the absence of pathogens, Arabidopsis MAP kinase 4 (MPK4) exists in nuclear complexes with the WRKY33 transcription factor. This complex depends on the MPK4 substrate MKS1. Challenge with Pseudomonas syringae or flagellin leads to the activation of MPK4 and phosphorylation of MKS1. Subsequently, complexes with MKS1 and WRKY33 are released from MPK4, and WRKY33 targets the promoter of PHYTOALEXIN DEFICIENT3 (PAD3) encoding an enzyme required for the synthesis of antimicrobial camalexin. Hence, wrky33 mutants are impaired in the accumulation of PAD3 mRNA and camalexin production upon infection. That WRKY33 is an effector of MPK4 is further supported by the suppression of PAD3 expression in mpk4-wrky33 double mutant backgrounds. Our data establish direct links between MPK4 and innate immunity and provide an example of how a plant MAP kinase can regulate gene expression by releasing transcription factors in the nucleus upon activation.
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