ArticleKidney international2008
Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching.
Article in Kidney international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Duplex kidney formation: developmental mechanisms and genetic predisposition.F1000Research · 2020Review
- Programmed Adult Kidney Disease: Importance of Fetal Environment.Frontiers in physiology · 2020Review
- Adhesion GPCRs in Kidney Development and Disease.Frontiers in cell and developmental biology · 2018Review
- Foxd1 is an upstream regulator of the renin-angiotensin system during metanephric kidney development.Pediatric research · 2017Article
- Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models.Physiological genomics · 2017Review
- The molecular signature and spermatogenesis potential of newborn chicken spermatogonial stem cells in vitro.In vitro cellular & developmental biology. Animal · 2015Article
- Renin-angiotensin system in ureteric bud branching morphogenesis: implications for kidney disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- How the kidney is impacted by the perinatal maternal environment to develop hypertension.Biology of reproduction · 2013Review
- Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats.Pediatric nephrology (Berlin, Germany) · 2011Article
- Renin-angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms.Pediatric nephrology (Berlin, Germany) · 2011Review
- Genetics of congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2011Review
- Receptor tyrosine kinases in kidney development.Journal of signal transduction · 2011Article
- Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells.Molecular vision · 2010Article
- Histone deacetylases are critical regulators of the renin-angiotensin system during ureteric bud branching morphogenesis.Pediatric research · 2010Article
- Angiotensin II AT2 receptor regulates ureteric bud morphogenesis.American journal of physiology. Renal physiology · 2010Article
- Renin-angiotensin system-growth factor cross-talk: a novel mechanism for ureteric bud morphogenesis.Pediatric nephrology (Berlin, Germany) · 2009Review
- Angiotensin II stimulates in vitro branching morphogenesis of the isolated ureteric bud.Mechanisms of developmentArticle
- Angiotensin II-induced activation of c-Ret signaling is critical in ureteric bud branching morphogenesis.Mechanisms of developmentArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mutations of genes in the renin-angiotensin system are associated with congenital abnormalities of the kidney and urinary tract. The major signaling pathway for branching morphogenesis during kidney development is the c-Ret receptor tyrosine kinase whose ligand is GDNF and whose downstream target is Wnt11. We determined whether angiotensin II, an inducer of ureteric bud branching in vitro, influences the GDNF/c-Ret/Wnt11 pathway. Mouse metanephroi were grown in the presence or absence of angiotensin II or an angiotensin type 1 receptor (AT1R) antagonist and gene expression was measured by whole mount in situ hybridization. Angiotensin II induced the expression of c-Ret and Wnt11 in ureteric bud tip cells. GDNF, a Wnt11-regulated gene expressed in the mesenchyme, was also upregulated by angiotensin II but this downregulated Spry1, an endogenous inhibitor of Ret tyrosine kinase activity in an AT1R-dependent manner. Angiotensin II also decreased Spry1 mRNA levels in cultured ureteric bud cells. Exogenous angiotensin II preferentially stimulated ureteric bud tip cell proliferation in vivo while AT1R blockade increased cell apoptosis. Our findings suggest AT1R-mediated inhibition of the Spry1 gene increases c-Ret tyrosine kinase activity leading to upregulation of its downstream target Wnt11. Enhanced Wnt11 expression induces GDNF in adjacent mesenchyme causing focal bursts of ureteric bud tip cell proliferation, decreased tip cell apoptosis and branching.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.