ArticleProceedings of the National Academy of Sciences of the United States of America2008
Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Sex-Specific Landscapes of Crossover and Noncrossover Recombination in Coppery Titi Monkeys (Plecturocebus cupreus).Genome biology and evolution · 2026Article
- Insights into non-crossover recombination from long-read sperm sequencing.bioRxiv : the preprint server for biology · 2024Article
- High-Resolution Estimates of Crossover and Noncrossover Recombination from a Captive Baboon Colony.Genome biology and evolution · 2022Article
- Fine human genetic map based on UK10K data set.Human genetics · 2022Article
- Evidence for a force favoring GC over AT at short intronic sites in Drosophila simulans and Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- Meiosis and beyond - understanding the mechanistic and evolutionary processes shaping the germline genome.Biological reviews of the Cambridge Philosophical Society · 2021Review
- Chromosome-wide characterization of meiotic noncrossovers (gene conversions) in mouse hybrids.Genetics · 2021Article
- A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination.Nature communications · 2019Article
- The impact of poly-A microsatellite heterologies in meiotic recombination.Life science alliance · 2019Article
- Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm.Science (New York, N.Y.) · 2019Article
- Recombination hotspots in an extended human pseudoautosomal domain predicted from double-strand break maps and characterized by sperm-based crossover analysis.PLoS genetics · 2018Article
- Predicting human genes susceptible to genomic instability associated withGenome research · 2018Article
- Meiotic crossovers are associated with open chromatin and enriched with Stowaway transposons in potato.Genome biology · 2017Article
- Recombination rate variation in mice from an isolated island.Molecular ecology · 2017Article
- The rate of meiotic gene conversion varies by sex and age.Nature genetics · 2016Article
- Article
- Crossovers are associated with mutation and biased gene conversion at recombination hotspots.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- DNA recombination. Recombination initiation maps of individual human genomes.Science (New York, N.Y.) · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Population diversity data have recently provided profound, albeit inferential, insights into meiotic recombination across the human genome, revealing a landscape dominated by thousands of cross-over hotspots. However, very few of these putative hotspots have been directly analyzed for cross-over activity. We now describe a search for very active hotspots, by using extreme breakdown of marker association as a guide for high-resolution sperm cross-over analysis. This strategy has led to the isolation of the most active cross-over hotspots yet described. Their morphology, sequence attributes, and cross-over processes are very similar to those seen at less active hotspots, but their activity in sperm is poorly predicted from population diversity information. Several of these hotspots showed evidence for biased gene conversion accompanying cross-over, in some cases associated with variation between men in cross-over activity and with two hotspots showing complete presence/absence polymorphism in different men. Hotspot polymorphism is very common at less active hotspots but curiously was not seen at any of the most active hotspots. This contrasts with the prediction that extreme hotspots should be the most vulnerable to attenuation by meiotic drive in favor of mutations that suppress recombination and should therefore show rapid rate evolution and thus variation in activity between men. Finally, these very intense hotspots provide a valuable resource for dissecting meiotic recombination processes and pathways in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.