ArticleProceedings of the National Academy of Sciences of the United States of America2008
Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 region.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Altered NPTX2 dynamics associated with impaired cognitive aging.bioRxiv : the preprint server for biology · 2025Article
- Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity.Science advances · 2025Article
- Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients.Biomolecules · 2022Article
- Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Aged rats with intact memory show distinctive recruitment in cortical regions relative to young adults in a cue mismatch task.Behavioral neuroscience · 2019Article
- Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment.Neurobiology of aging · 2019Article
- Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.Non-coding RNA · 2018Article
- Head west or left, east or right: interactions between memory systems in neurocognitive aging.Neurobiology of aging · 2015Article
- Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The neuronal activity-driven transcriptome.Molecular neurobiology · 2015Review
- Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia.Oxidative medicine and cellular longevity · 2013Article
- Article
- Gene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and Wnt signaling in epileptogenesis.PloS one · 2013Article
- Neurexins and neuroligins: synapses look out of the nervous system.Cellular and molecular life sciences : CMLS · 2011Review
- Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Region-specific genetic alterations in the aging hippocampus: implications for cognitive aging.Frontiers in aging neuroscience · 2010Article
- The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Statistical evaluation of methods for quantifying gene expression by autoradiography in histological sections.BMC neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a spatial learning protocol to engage a pattern separation function to encode new information. After background training, two groups of animals experienced the same new training in a novel environment; however, only one group was provided spatial information and demonstrated spatial memory in a retention test. Global transcriptional analysis of the microdissected subregions of the hippocampus exposed a CA3 pattern that was sufficient to clearly segregate spatial learning animals from control. Individual gene and functional group analysis anchored these results to previous work in neural plasticity. From a multitude of expression changes, increases in camk2a, rasgrp1, and nlgn1 were confirmed by in situ hybridization. Furthermore, siRNA inhibition of nlgn1 within the CA3 subregion impaired spatial memory performance, pointing to mechanisms of synaptic remodeling as a basis for rapid encoding of new information in long-term memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.