ArticleJournal of clinical microbiology2008
Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Progression of antibiotic resistance inClinical microbiology reviews · 2025Review
- Genomic Diversity and Antimicrobial Susceptibility of Invasive Neisseria meningitidis in South Africa, 2016-2021.The Journal of infectious diseases · 2024Article
- Article
- Genetic characterization ofFrontiers in cellular and infection microbiology · 2024Article
- Serogroup Y Clonal Complex 23 Meningococcus in China Acquiring Penicillin Resistance from Commensal Neisseria lactamica Species.Antimicrobial agents and chemotherapy · 2022Article
- Antibiotic resistance among invasive Neisseria meningitidis isolates in England, Wales and Northern Ireland (2010/11 to 2018/19).PloS one · 2021Article
- Article
- Penicillin Use in Meningococcal Disease Management: Active Bacterial Core Surveillance Sites, 2009.Open forum infectious diseases · 2016Article
- Use of Animal Models To Support Revising Meningococcal Breakpoints of β-Lactams.Antimicrobial agents and chemotherapy · 2016Article
- Population-Based Surveillance of Neisseria meningitidis Antimicrobial Resistance in the United States.Open forum infectious diseases · 2015Article
- Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688.Journal of clinical microbiology · 2012Article
- Population snapshot of invasive serogroup B meningococci in South Africa from 2005 to 2008.Journal of clinical microbiology · 2012Article
- Evolutionary changes in antimicrobial resistance of invasive Neisseria meningitidis isolates in Belgium from 2000 to 2010: increasing prevalence of penicillin nonsusceptibility.Antimicrobial agents and chemotherapy · 2012Article
- Article
- Novel classes of antibiotics or more of the same?British journal of pharmacology · 2011Review
- Antimicrobial resistance surveillance systems: Are potential biases taken into account?The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2011Article
- Article
- Critical appraisal of a quadrivalent CRM(197) conjugate vaccine against meningococcal serogroups A, C W-135 and Y (Menveo) in the context of treatment and prevention of invasive disease.Infection and drug resistance · 2011Article
- Extensive genomic variation within clonal complexes of Neisseria meningitidis.Genome biology and evolution · 2011Article
- Epidemiology of invasive meningococcal disease with decreased susceptibility to penicillin in Ontario, Canada, 2000 to 2006.Antimicrobial agents and chemotherapy · 2010Article
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6 authors.
Funding
Abstract
Neisseria meningitidis strains (meningococci) with decreased susceptibility to penicillin (MICs, >0.06 microg/ml) have been reported in several parts of the world, but the prevalence of such isolates in Africa is poorly described. Data from an active national laboratory-based surveillance program from January 2001 through December 2005 were analyzed. A total of 1,897 cases of invasive meningococcal disease were reported, with an average annual incidence of 0.83/100,000 population. Of these cases, 1,381 (73%) had viable isolates available for further testing; 87 (6%) of these isolates tested intermediately resistant to penicillin (Pen(i)). Pen(i) meningococcal isolates were distributed throughout all provinces and age groups, and there was no association with outcome or human immunodeficiency virus infection. The prevalence of Pen(i) was lower in serogroup A (7/295; 2%) than in serogroup B (24/314; 8%), serogroup C (9/117; 8%), serogroup Y (22/248; 9%), or serogroup W135 (25/396; 6%) (P = 0.02). Pulsed-field gel electrophoresis grouped 63/82 Pen(i) isolates into nine clusters, mostly according to serogroup. The clustering of patterns from Pen(i) isolates was not different from that of penicillin-susceptible isolates. Twelve sequence types were identified among 18 isolates arbitrarily selected for multilocus sequence typing. DNA sequence analysis of the penA gene identified 26 different alleles among the Pen(i) isolates. Intermediate penicillin resistance is thus widespread among meningococcal serogroups, has been selected in a variety of lineages, and, to date, does not appear to be associated with increased mortality. This is the first report describing the prevalence and molecular epidemiology of Pen(i) meningococcal isolates from sub-Saharan Africa.
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