ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
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- Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons.bioRxiv : the preprint server for biology · 2023Article
- The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Review
- Signaling - transcription interactions in mouse retinal ganglion cells early axon pathfinding -a literature review.Frontiers in ophthalmology · 2023Review
- Revisiting the role of Dcc in visual system development with a novel eye clearing method.eLife · 2020Article
- Genetic Analysis of the Organization, Development, and Plasticity of Corneal Innervation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish.Mechanisms of development · 2018Article
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- Sound-Evoked Activity Influences Myelination of Brainstem Axons in the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain.Annual review of neuroscience · 2017Review
- Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System.Physiological reviews · 2017Review
- Simulations on the influence of myelin water in diffusion-weighted imaging.Physics in medicine and biology · 2016Article
- The microstructural correlates of T1 in white matter.Magnetic resonance in medicine · 2016Article
- Caspr2 autoantibodies target multiple epitopes.Neurology(R) neuroimmunology & neuroinflammation · 2015Article
- Article
- Frequency shifts in the myelin water compartment.Magnetic resonance in medicine · 2014Article
- Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Micro-compartment specific T2* relaxation in the brain.NeuroImage · 2013Article
- Neuronal autoantigens--pathogenesis, associated disorders and antibody testing.Nature reviews. Neurology · 2012Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter axons organize into fascicles that grow over long distances and traverse very diverse environments. The molecular mechanisms preserving this structure of white matter axonal tracts are not well known. Here, we used the optic nerve as a model and investigated the role of TAG-1, a cell adhesion molecule expressed by retinal axons. TAG-1 was first expressed in the embryonic retinal ganglion cells (RGCs) and later in the postnatal myelin-forming cells in the optic nerve. We describe the consequences of genetic loss of Tag-1 on the developing and adult retinogeniculate tract. Tag-1-null embryos display anomalies in the caliber of RGC axons, associated with an abnormal organization of the astroglial network in the optic nerve. The contralateral projections in the lateral geniculate nucleus are expanded postnatally. In the adult, Tag-1-null mice show a loss of RGC axons, with persistent abnormalities of axonal caliber and additional cytoskeleton and myelination defects. Therefore, TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.