ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed.
- Compensatory coupling between leak and HCN conductances defines a low dimensional solution manifold in GPe neuron subtypes.Scientific reports · 2026Article
- Temporal Variability in the Spiking Activity of Neurons in the External Globus Pallidus in Healthy and Parkinsonian Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- Morphological details contribute to neuronal response variability within the same cell type.Frontiers in cellular neuroscience · 2026Article
- A universal workflow for creation, validation, and generalization of detailed neuronal models.Patterns (New York, N.Y.) · 2023Article
- Biological complexity facilitates tuning of the neuronal parameter space.PLoS computational biology · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Pareto optimality, economy-effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons.Open biology · 2022Review
- Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Initial Variability and Time-Dependent Changes of Neuronal Response Features Are Cell-Type-Specific.Frontiers in cellular neuroscience · 2022Article
- BOLD Monitoring in the Neural Simulator ANNarchy.Frontiers in neuroinformatics · 2022Article
- On the Role of Arkypallidal and Prototypical Neurons for Phase Transitions in the External Pallidum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit.Scientific reports · 2021Article
- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neuronal population model of globular bushy cells covering unit-to-unit variability.PLoS computational biology · 2019Article
- Dimensions of control for subthreshold oscillations and spontaneous firing in dopamine neurons.PLoS computational biology · 2019Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
18 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Globus pallidus (GP) neurons recorded in brain slices show significant variability in intrinsic electrophysiological properties. To investigate how this variability arises, we manipulated the biophysical properties of GP neurons using computer simulations. Specifically, we created a GP neuron model database with 100,602 models that had varying densities of nine membrane conductances centered on a hand-tuned model that replicated typical physiological data. To test the hypothesis that the experimentally observed variability can be attributed to variations in conductance densities, we compared our model database results to a physiology database of 146 slice recordings. The electrophysiological properties of generated models and recordings were assessed with identical current injection protocols and analyzed with a uniform set of measures, allowing a systematic analysis of the effects of varying voltage-gated and calcium-gated conductance densities on the measured properties and a detailed comparison between models and recordings. Our results indicated that most of the experimental variability could be matched by varying conductance densities, which we confirmed with additional partial block experiments. Further analysis resulted in two key observations: (1) each voltage-gated conductance had effects on multiple measures such as action potential waveform and spontaneous or stimulated spike rates; and (2) the effect of each conductance was highly dependent on the background context of other conductances present. In some cases, such interactions could reverse the effect of the density of one conductance on important excitability measures. This context dependence of conductance density effects is important to understand drug and neuromodulator effects that work by affecting ion channels.
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