ArticleJournal of neurophysiology2008
Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 108 citations in OpenAlex.
- Modeling insights into potential mechanisms of opioid-induced respiratory depression within medullary and pontine networks.Journal of neurophysiology · 2026Article
- Development and characterization of an autoresuscitation test for preclinical SUDEP models.Epilepsia · 2025Article
- Peripheral antitussives affect temporal features of tracheobronchial coughing in cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping.Journal of neurophysiology · 2024Article
- Latent neural population dynamics underlying breathing, opioid-induced respiratory depression and gasping.Nature neuroscience · 2024Article
- Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Revisiting the two rhythm generators for respiration in lampreys.Frontiers in neuroanatomy · 2023Article
- Changes in pontine and preBötzinger/Bötzinger complex neuronal activity during remifentanil-induced respiratory depression in decerebrate dogs.Frontiers in physiology · 2023Article
- Fentanyl effects on respiratory neuron activity in the dorsolateral pons.Journal of neurophysiology · 2022Article
- Breathing rate variability in obstructive sleep apnea during wakefulness.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- The sigh and related behaviors.Handbook of clinical neurology · 2022Review
- Cough as a Cause and Consequence of Heart Dysfunction - Current State of Art.Physiological research · 2020Review
- Diaphragm muscle sarcopenia into very old age in mice.Physiological reports · 2020Article
- Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency.Respiratory physiology & neurobiology · 2019Article
- Reduced computational modelling of Kölliker-Fuse contributions to breathing patterns in Rett syndrome.The Journal of physiology · 2019Article
- Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.Comprehensive physiology · 2019Review
- The contribution of endogenous glutamatergic input in the ventral respiratory column to respiratory rhythm.Respiratory physiology & neurobiology · 2019Article
- Pulmonary Vein Ganglia Are Remodeled in the Diabetic Heart.Journal of the American Heart Association · 2018Article
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Organization of the core respiratory network: Insights from optogenetic and modeling studies.PLoS computational biology · 2018Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
A large body of data suggests that the pontine respiratory group (PRG) is involved in respiratory phase-switching and the reconfiguration of the brain stem respiratory network. However, connectivity between the PRG and ventral respiratory column (VRC) in computational models has been largely ad hoc. We developed a network model with PRG-VRC connectivity inferred from coordinated in vivo experiments. Neurons were modeled in the "integrate-and-fire" style; some neurons had pacemaker properties derived from the model of Breen et al. We recapitulated earlier modeling results, including reproduction of activity profiles of different respiratory neurons and motor outputs, and their changes under different conditions (vagotomy, pontine lesions, etc.). The model also reproduced characteristic changes in neuronal and motor patterns observed in vivo during fictive cough and during hypoxia in non-rapid eye movement sleep. Our simulations suggested possible mechanisms for respiratory pattern reorganization during these behaviors. The model predicted that network- and pacemaker-generated rhythms could be co-expressed during the transition from gasping to eupnea, producing a combined "burst-ramp" pattern of phrenic discharges. To test this prediction, phrenic activity and multiple single neuron spike trains were monitored in vagotomized, decerebrate, immobilized, thoracotomized, and artificially ventilated cats during hypoxia and recovery. In most experiments, phrenic discharge patterns during recovery from hypoxia were similar to those predicted by the model. We conclude that under certain conditions, e.g., during recovery from severe brain hypoxia, components of a distributed network activity present during eupnea can be co-expressed with gasp patterns generated by a distinct, functionally "simplified" mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.