ArticleCell communication & adhesion2008
Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore density.
Article in Cell communication & adhesion, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Mechanisms of permselectivity of connexin hemichannels to small molecules.The Journal of biological chemistry · 2025Article
- Connexin Gap Junction Channels and Hemichannels: Insights from High-Resolution Structures.Biology · 2024Review
- Recent advances in connexin gap junction biology.Faculty reviews · 2022Review
- An Overview of Microcrystal Electron Diffraction (MicroED).Annual review of biochemistry · 2021Review
- Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Biochimica et biophysica acta. Biomembranes · 2018Review
- A structural and functional comparison of gap junction channels composed of connexins and innexins.Developmental neurobiology · 2017Review
- Mechanism of gating by calcium in connexin hemichannels.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus.Biophysical journal · 2016Article
- Voltage regulation of connexin channel conductance.Yonsei medical journal · 2015Review
- Gap junction regulation by calmodulin.FEBS letters · 2014Review
- Functional analysis and regulation of purified connexin hemichannels.Frontiers in physiology · 2014Review
- A history of gap junction structure: hexagonal arrays to atomic resolution.Cell communication & adhesion · 2013Review
- Article
- Structural basis for the selective permeability of channels made of communicating junction proteins.Biochimica et biophysica acta · 2013Review
- Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues.Biochimica et biophysica acta · 2012Review
- Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure.Biochimica et biophysica acta · 2012Review
- Voltage-dependent conformational changes in connexin channels.Biochimica et biophysica acta · 2012Review
- Structure of the gap junction channel and its implications for its biological functions.Cellular and molecular life sciences : CMLS · 2011Review
- Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.Journal of molecular biology · 2011Article
- The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes.Journal of structural biology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Gated gap junction channels are important cellular conduits for establishing and maintaining intercellular communication. The three-dimensional structure of a mutant human connexin 26 (Cx26M34A) by electron cryocrystallography revealed a plug-like density in the channel pore suggesting that physical blockage of the pore may be one mechanism of closure (Oshima et al. 2007, Proc Natl Acad Sci USA 104: 10034-10039). However, it remains to be determined what part of the sequence contributes to the plug. Here, we present the projection structure of an N-terminus deletion of Cx26M34A missing amino acids 2 to 7 (Cx26M34Adel2-7) crystallized in the same two-dimensional crystal form. A 10 A resolution projection map of Cx26M34Adel2-7 revealed that the plug density was dramatically reduced in comparison with that found in full-length Cx26 channel. The difference map between the deletion and full-length Cx26M34A channels strongly suggests that the N-terminus of connexin contributes to the plug for the physical closure of gap junction channels.
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