ReviewJournal of bioenergetics and biomembranes2008
Reflections on VDAC as a voltage-gated channel and a mitochondrial regulator.
Review in Journal of bioenergetics and biomembranes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Multiple entanglements of different cell death pathways, in which caspase-8 and BID interact with cardiolipin*, have been identified.Frontiers in cell and developmental biology · 2025Review
- ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs.Cell research · 2024Article
- Identification of Biomarkers Affecting Cryopreservation Recovery Ratio in Ram Spermatozoa Using Tandem Mass Tags (TMT)-Based Quantitative Proteomics Approach.Animals : an open access journal from MDPI · 2023Article
- The Open State Selectivity of the Bean Seed VDAC Depends on Stigmasterol and Ion Concentration.International journal of molecular sciences · 2021Article
- Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1.Scientific reports · 2018Article
- Revisiting trends on mitochondrial mega-channels for the import of proteins and nucleic acids.Journal of bioenergetics and biomembranes · 2017Review
- VDAC2-specific cellular functions and the underlying structure.Biochimica et biophysica acta · 2016Review
- The Association of VDAC with Cell Viability of PC12 Model of Huntington's Disease.Frontiers in oncology · 2016Article
- Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity.Biochimica et biophysica acta · 2014Review
- Bcl-xL in neuroprotection and plasticity.Frontiers in physiology · 2014Review
- Tissue plasminogen activator regulates Purkinje neuron development and survival.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.Brain research · 2012Article
- Phylogenetic analysis of mitochondrial outer membrane β-barrel channels.Genome biology and evolution · 2012Article
- VDAC contributes to mRNA levels in Saccharomyces cerevisiae cells by the intracellular reduction/oxidation state dependent and independent mechanisms.Journal of bioenergetics and biomembranes · 2010Article
- Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.The Journal of biological chemistry · 2010Article
- Article
- Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target.Cancer biology & therapy · 2010Article
- Mitochondrial ion channels as therapeutic targets.FEBS letters · 2010Review
- Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels.FEBS letters · 2010Review
- Apoptosis: it's BAK to VDAC.EMBO reports · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
There is excellent agreement between the electrophysiological properties and the structure of the mitochondrial outer membrane protein, VDAC, ex vivo. However, the inference that the well-defined canonical "open" state of the VDAC pore is the normal physiological state of the channel in vivo is being challenged by several lines of evidence. Knowing the atomic structure of the detergent solubilized protein, a long sought after goal, will not be sufficient to understand the functioning of this channel protein. In addition, detailed information about VDAC's topology in the outer membrane of intact mitochondria, and the structural changes that it undergoes in response to different stimuli in the cell will be needed to define its physiological functions and regulation.
Indexed as
Identifiers
18648913What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.