ArticleHistochemistry and cell biology2008
A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 87 citations in OpenAlex.
- Article
- A proteomic-based approach to study underlying molecular responses of the small intestine of Wistar rats to genetically modified corn (MON810).Transgenic research · 2019Article
- RoundupToxics · 2019Article
- Cornell Alliance for Science Evaluation of Consensus on Genetically Modified Food Safety: Weaknesses in Study Design.Frontiers in public health · 2017Article
- Effects of Genetically Modified Milk Containing Human Beta-Defensin-3 on Gastrointestinal Health of Mice.PloS one · 2016Article
- Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure.Environmental health : a global access science source · 2015Article
- Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize.Environmental sciences Europe · 2014Article
- Assessment of the impact of genetically modified LibertyLinkToxicology reports · 2014Article
- The use of whole food animal studies in the safety assessment of genetically modified crops: limitations and recommendations.Critical reviews in toxicology · 2013Review
- GMOs in animal agriculture: time to consider both costs and benefits in regulatory evaluations.Journal of animal science and biotechnology · 2013Article
- How safe does transgenic food need to be?Nature biotechnology · 2013Article
- Scientific Opinion on applications (EFSA-GMO-RX-40-3-2EFSA journal. European Food Safety Authority · 2010Article
- State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.