ArticleDose-response : a publication of International Hormesis Society2006
Stochastic thresholds: a novel explanation of nonlinear dose-response relationships for stochastic radiobiological effects.
Article in Dose-response : a publication of International Hormesis Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Low-dose or low-dose-rate ionizing radiation-induced bioeffects in animal models.Journal of radiation research · 2017Review
- Low-radiation environment affects the development of protection mechanisms in V79 cells.Radiation and environmental biophysics · 2015Article
- Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy.Journal of cell communication and signaling · 2014Article
- Donor-specific cell-based assays in studying sensitivity to low-dose radiation: a population-based perspective.Frontiers in public health · 2014Review
- Potential treatment of inflammatory and proliferative diseases by ultra-low doses of ionizing radiations.Dose-response : a publication of International Hormesis Society · 2012Article
- Modeling DNA double-strand break repair kinetics as an epiregulated cell-community-wide (epicellcom) response to radiation stress.Dose-response : a publication of International Hormesis Society · 2011Article
- Stochastic threshold microdose model for cell killing by insoluble metallic nanomaterial particles.Dose-response : a publication of International Hormesis Society · 2010Article
- Special issue introduction.Dose-response : a publication of International Hormesis Society · 2010Article
- Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer.Dose-response : a publication of International Hormesis Society · 2009Article
- A review: Development of a microdose model for analysis of adaptive response and bystander dose response behavior.Dose-response : a publication of International Hormesis Society · 2008Article
- It's time for a new low-dose-radiation risk assessment paradigm--one that acknowledges hormesis.Dose-response : a publication of International Hormesis Society · 2008Article
- Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation.Dose-response : a publication of International Hormesis Society · 2008Article
- Low-dose-radiation stimulated natural chemical and biological protection against lung cancer.Dose-response : a publication of International Hormesis Society · 2008Article
- Extremely low doses of X-radiation can induce adaptive responses in mouse prostate.Dose-response : a publication of International Hormesis Society · 2007Article
- Sparsely ionizing diagnostic and natural background radiations are likely preventing cancer and other genomic-instability-associated diseases.Dose-response : a publication of International Hormesis Society · 2006Article
- Radiation-induced neoplastic transformation in vitro, hormesis and risk assessment.Dose-response : a publication of International Hormesis Society · 2006Article
- Smoking and hormesis as confounding factors in radiation pulmonary carcinogenesis.Dose-response : a publication of International Hormesis Society · 2006Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New research data for low-dose, low-linear energy transfer (LET) radiation-induced, stochastic effects (mutations and neoplastic transformations) are modeled using the recently published NEOTRANS(3) model. The model incorporates a protective, stochastic threshold (StoThresh) at low doses for activating cooperative protective processes considered to include presumptive p53-dependent, high-fidelity repair of nuclear DNA damage in competition with presumptive p53-dependent apoptosis and a novel presumptive p53-independent protective apoptosis mediated (PAM) process which selectively removes genomically compromised cells (mutants, neoplastic transformants, micronucleated cells, etc.). The protective StoThresh are considered to fall in a relatively narrow low-dose zone (Transition Zone A). Below Transition Zone A is the ultra-low-dose region where it is assumed that only low-fidelity DNA repair is activated along with presumably apoptosis. For this zone there is evidence for an increase in mutations with increases in dose. Just above Transition Zone A, a Zone of Maximal Protection (suppression of stochastic effects) arises and is attributed to maximal cooperation of high-fidelity, DNA repair/apoptosis and the PAM process. The width of the Zone of Maximal Protection depends on low-LET radiation dose rate and appears to depend on photon radiation energy. Just above the Zone of Maximal Protection is Transition Zone B, where deleterious StoThresh for preventing the PAM process fall. Just above Transition Zone B is a zone of moderate doses where complete inhibition of the PAM process appears to occur. However, for both Transition Zone B and the zone of complete inhibition of the PAM process, high-fidelity DNA repair/apoptosis are presumed to still operate. The indicated protective and deleterious StoThresh lead to nonlinear, hormetic-type dose-response relationships for low-LET radiation-induced mutations, neoplastic transformation and, presumably, also for cancer.
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