ArticleDose-response : a publication of International Hormesis Society2007
Protective bystander effects simulated with the state-vector model.
Article in Dose-response : a publication of International Hormesis Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- REVIEW OF QUANTITATIVE MECHANISTIC MODELS OF RADIATION-INDUCED NON-TARGETED EFFECTS (NTE).Radiation protection dosimetry · 2020Review
- A review: Development of a microdose model for analysis of adaptive response and bystander dose response behavior.Dose-response : a publication of International Hormesis Society · 2008Article
- Systems biological and mechanistic modelling of radiation-induced cancer.Radiation and environmental biophysics · 2008Review
- "Protective bystander effects simulated with the state-vector model"--HeLa x skin exposure to Cs not protective bystander response but mammogram and diagnostic X-rays are.Dose-response : a publication of International Hormesis Society · 2008Article
- Detrimental and protective bystander effects: a model approach.Radiation research · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Apoptosis induced in non-hit bystander cells is an important biological mechanism which operates after exposure to low doses of low-LET radiation. This process was implemented into a deterministic multistage model for in vitro neoplastic transformation: the State-Vector Model (SVM). The new model is tested on two data sets that show a reduction of the transformation frequency below the spontaneous level after exposure of the human hybrid cell line CGL1 to low doses of gamma-radiation. Stronger protective effects are visible in the data for delayed plating while the data for immediate plating show more of an LNT-like dose-response curve. It is shown that the model can describe both data sets. The calculation of the time-dependent numerical solution of the model also allows to obtain information about the time-dependence of the protective apoptosis-mediated process after low dose exposures. These findings are compared with experimental observations after high dose exposures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.