ArticleDose-response : a publication of International Hormesis Society2006
Sparsely ionizing diagnostic and natural background radiations are likely preventing cancer and other genomic-instability-associated diseases.
Article in Dose-response : a publication of International Hormesis Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Contemporary opportunities and potential of Auger electron-emitting theranostics.Theranostics · 2026Review
- Different responses of normal cells (red blood cells) and cancer cells (K562 and K562/Dox cells) to low-doseMolecular and clinical oncology · 2021Article
- Low-dose or low-dose-rate ionizing radiation-induced bioeffects in animal models.Journal of radiation research · 2017Review
- Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos.International journal of molecular sciences · 2017Article
- A calibration method for realistic neutron dosimetry in radiobiological experiments assisted by MCNP simulation.Journal of radiation research · 2016Article
- Non-induction of radioadaptive response in zebrafish embryos by neutrons.Journal of radiation research · 2016Article
- Potential treatment of inflammatory and proliferative diseases by ultra-low doses of ionizing radiations.Dose-response : a publication of International Hormesis Society · 2012Article
- Cancer mortality, state mean elevations, and other selected predictors.Dose-response : a publication of International Hormesis Society · 2012Article
- No Evidence for the In Vivo Induction of Genomic Instability by Low Doses of CS Gamma Rays in Bone Marrow Cells of BALB/CJ and C57BL/6J Mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Identification of proteins secreted into the medium by human lymphocytes irradiated in vitro with or without adaptive environments.Health physics · 2012Article
- Assessing potential radiological harm to fukushima recovery workers.Dose-response : a publication of International Hormesis Society · 2011Article
- Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders.Antioxidants & redox signaling · 2010Review
- Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes.Neurochemical research · 2010Article
- Twilight effects of low doses of ionizing radiation on cellular systems: a bird's eye view on current concepts and research.Medical oncology (Northwood, London, England) · 2010Review
- Cancer mortality in six lowest versus six highest elevation jurisdictions in the u.s.Dose-response : a publication of International Hormesis Society · 2010Article
- Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment.Dose-response : a publication of International Hormesis Society · 2010Article
- Special issue introduction.Dose-response : a publication of International Hormesis Society · 2010Article
- Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer.Dose-response : a publication of International Hormesis Society · 2009Article
- A perspective on the scientific, philosophical, and policy dimensions of hormesis.Dose-response : a publication of International Hormesis Society · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Routine diagnostic X-rays (e.g., chest X-rays, mammograms, computed tomography scans) and routine diagnostic nuclear medicine procedures using sparsely ionizing radiation forms (e.g., beta and gamma radiations) stimulate the removal of precancerous neo-plastically transformed and other genomically unstable cells from the body (medical radiation hormesis). The indicated radiation hormesis arises because radiation doses above an individual-specific stochastic threshold activate a system of cooperative protective processes that include high-fidelity DNA repair/apoptosis (presumed p53 related), an auxiliary apoptosis process (PAM process) that is presumed p53-independent, and stimulated immunity. These forms of induced protection are called adapted protection because they are associated with the radiation adaptive response. Diagnostic X-ray sources, other sources of sparsely ionizing radiation used in nuclear medicine diagnostic procedures, as well as radioisotope-labeled immunoglobulins could be used in conjunction with apoptosis-sensitizing agents (e.g., the natural phenolic compound resveratrol) in curing existing cancer via low-dose fractionated or low-dose, low-dose-rate therapy (therapeutic radiation hormesis). Evidence is provided to support the existence of both therapeutic (curing existing cancer) and medical (cancer prevention) radiation hormesis. Evidence is also provided demonstrating that exposure to environmental sparsely ionizing radiations, such as gamma rays, protect from cancer occurrence and the occurrence of other diseases via inducing adapted protection (environmental radiation hormesis).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.