ArticleDose-response : a publication of International Hormesis Society2006
Radiation-induced neoplastic transformation in vitro, hormesis and risk assessment.
Article in Dose-response : a publication of International Hormesis Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts.International journal of molecular sciences · 2021Review
- Correcting systemic deficiencies in our scientific infrastructure.Dose-response : a publication of International Hormesis Society · 2014Article
- Computational modeling of cellular effects post-irradiation with low- and high-let particles and different absorbed doses.Dose-response : a publication of International Hormesis Society · 2013Article
- The new radiobiology: returning to our roots.Dose-response : a publication of International Hormesis Society · 2012Article
- Human Lung Cancer Risks from Radon - Part III - Evidence of Influence of Combined Bystander and Adaptive Response Effects on Radon Case-Control Studies - A Microdose Analysis.Dose-response : a publication of International Hormesis Society · 2012Article
- A stochastic markov model of cellular response to radiation.Dose-response : a publication of International Hormesis Society · 2011Article
- Human Lung Cancer Risks from Radon - Part II - Influence from Combined Adaptive Response and Bystander Effects - A Microdose Analysis.Dose-response : a publication of International Hormesis Society · 2011Article
- Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders.Antioxidants & redox signaling · 2010Review
- Immunological mechanism of the low-dose radiation-induced suppression of cancer metastases in a mouse model.Dose-response : a publication of International Hormesis Society · 2009Article
- A perspective on the scientific, philosophical, and policy dimensions of hormesis.Dose-response : a publication of International Hormesis Society · 2009Article
- A review: Development of a microdose model for analysis of adaptive response and bystander dose response behavior.Dose-response : a publication of International Hormesis Society · 2008Article
- Non-problematic risks from low-dose radiation-induced DNA damage clusters.Dose-response : a publication of International Hormesis Society · 2008Article
- It's time for a new low-dose-radiation risk assessment paradigm--one that acknowledges hormesis.Dose-response : a publication of International Hormesis Society · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dose-response curves for various low-LET radiation sources have consistently been demonstrated to be J-shaped for the cancer-relevant endpoint of neoplastic transformation in vitro. Most of these studies have been performed where the radiation has been delivered at intermediate to high dose-rates (30-3000 mGy/min), where the threshold dose for induction of neoplastic transformation is around 100-200 mGy. Below these doses, the transformation frequency is less than that seen spontaneously, indicative of a hormetic effect. More recently, data have been obtained for low dose rates (<0.5 mGy/min) of low-LET radiation, and again hormetic effects are apparent but with threshold doses now being >1000 mGy. Similar trends have been reported in animal experiments as well as in human epidemiologic studies. Indeed, the relative risks for induction of neoplastic transformation in vitro in the dose range 1 to 1000 mGy agree well with those for incidence of radiation-induced breast cancer and leukemia in humans. These findings support the notion that the endpoint of neoplastic transformation in vitro is a plausible endpoint to not only study mechanisms involved in response to low doses of radiation, but also to provide information of potential importance to risk assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.