ArticleDose-response : a publication of International Hormesis Society2007
Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy.
Article in Dose-response : a publication of International Hormesis Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Hormetic and synergistic effects of cancer treatments revealed by modelling combinations of radio - or chemotherapy with immunotherapy.BMC cancer · 2023Article
- Review
- REVIEW OF QUANTITATIVE MECHANISTIC MODELS OF RADIATION-INDUCED NON-TARGETED EFFECTS (NTE).Radiation protection dosimetry · 2020Review
- Effective Doses of Ionizing Radiation during Therapeutic Peat Mud Treatment from a Deposit in the Knyszyn Forest (Northeastern Poland).International journal of environmental research and public health · 2020Article
- The role of dose rate in radiation cancer risk: evaluating the effect of dose rate at the molecular, cellular and tissue levels using key events in critical pathways following exposure to low LET radiation.International journal of radiation biology · 2016Review
- Response to Baverstock, K. Comments on Rithidech, K.N.; et al. Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation. Int. J. Environ. Res. Public Health 2013, 10, 1356-1377.International journal of environmental research and public health · 2013Article
- Linear No-Threshold Model VS. Radiation Hormesis.Dose-response : a publication of International Hormesis Society · 2013Article
- Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment.Dose-response : a publication of International Hormesis Society · 2010Article
- What physicians think about the need for informed consent for communicating the risk of cancer from low-dose radiation.Pediatric radiology · 2009Article
- It's time for a new low-dose-radiation risk assessment paradigm--one that acknowledges hormesis.Dose-response : a publication of International Hormesis Society · 2008Article
- Low-dose-radiation stimulated natural chemical and biological protection against lung cancer.Dose-response : a publication of International Hormesis Society · 2008Article
- Sparsely ionizing diagnostic and natural background radiations are likely preventing cancer and other genomic-instability-associated diseases.Dose-response : a publication of International Hormesis Society · 2006Article
- Smoking and hormesis as confounding factors in radiation pulmonary carcinogenesis.Dose-response : a publication of International Hormesis Society · 2006Article
- Stochastic thresholds: a novel explanation of nonlinear dose-response relationships for stochastic radiobiological effects.Dose-response : a publication of International Hormesis Society · 2006Article
- Radiophobia Harm, Its Main Cause, and a Proposed Solution.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A low-dose protective apoptosis-mediated (PAM) process is discussed that appears to be turned on by low-dose gamma and X rays but not by low-dose alpha radiation. PAM is a bystander effect that involves cross-talk between genomically compromised [e.g., mutants, neoplastically transformed, micronucleated] cells and nongenomically compromised cells. A novel neoplastic cell transformation model, NEOTRANS(3), is discussed that includes PAM. With NEOTRANS(3), PAM is activated by low doses and inhibited by moderate or high doses and is, therefore, a hormetic process. A low-dose region of suppression of the transformation frequency below the spontaneous frequency relates to the hormetic zone over which PAM is presumed to operate. The magnitude of suppression relates to what is called the hormetic intensity. Both the hormetic intensity and width of the hormetic zone are expected to depend on dose rate, being more pronounced after low dose rates. It is expected that PAM likely had a significant role in the following observations after chronic irradiation: (1) what appears to be a tremendous reduction in the cancer incidence below the spontaneous level for Taiwanese citizens residing for years in cobalt-60 contaminated apartments; and (2) the published reductions in the lung cancer incidence below the spontaneous level in humans after protracted X irradiation and after chronic gamma plus alpha irradiation. Implications of PAM for cancer prevention and low-dose cancer therapy are briefly discussed.
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