ArticleDose-response : a publication of International Hormesis Society2006
Radiation-induced bystander effects: evidence for an adaptive response to low dose exposures?
Article in Dose-response : a publication of International Hormesis Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed.
- Low-Dose Ionizing Radiation and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Review of Recent Evidence and Future Research Directions Toward the Elucidation of a Metabolic, Immunologic, and Signaling Cascade.International journal of molecular sciences · 2026Review
- Ionizing radiation-induced cancer: perplexities of the bystander effect.Ecancermedicalscience · 2023Review
- Low Radiation Environment Switches the Overgrowth-Induced Cell Apoptosis Toward Autophagy.Frontiers in public health · 2020Article
- Development of Targeted Alpha Particle Therapy for Solid Tumors.Molecules (Basel, Switzerland) · 2019Review
- Analysis of heteroplasmy in bank voles inhabiting the Chernobyl exclusion zone: A commentary on Baker et al. (2017) "Elevated mitochondrial genome variation after 50 generations of radiation exposure in a wild rodent."Evolutionary applications · 2018Article
- A reaction-diffusion model for radiation-induced bystander effects.Journal of mathematical biology · 2017Article
- Commentary: Human Pathophysiological Adaptations to the Space Environment.Frontiers in physiology · 2017Article
- Quantitative modeling of responses to chronic ionizing radiation exposure using targeted and non-targeted effects.PloS one · 2017Article
- Low Concentration of Exogenous Carbon Monoxide Modulates Radiation-Induced Bystander Effect in Mammalian Cell Cluster Model.International journal of molecular sciences · 2016Article
- Bystander effects and compartmental stress response to X-ray irradiation in L929 cells.Radiation and environmental biophysics · 2016Article
- An evaluation of novel real-time technology as a tool for measurement of radiobiological and radiation-induced bystander effects.Radiation and environmental biophysics · 2016Article
- The Role of Translational Regulation in Survival after Radiation Damage; an Opportunity for Proteomics Analysis.Proteomes · 2014Article
- Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response.Antioxidants & redox signaling · 2014Review
- Dying cells protect survivors from radiation-induced cell death in Drosophila.PLoS genetics · 2014Article
- Computational modeling of cellular effects post-irradiation with low- and high-let particles and different absorbed doses.Dose-response : a publication of International Hormesis Society · 2013Article
- Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress.Radiation research · 2011Article
- Article
- A stochastic markov model of cellular response to radiation.Dose-response : a publication of International Hormesis Society · 2011Article
- Radiation induced bystander effects in mice given low doses of radiation in vivo.Dose-response : a publication of International Hormesis Society · 2011Article
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reviews our current knowledge of the mechanisms underlying the induction of bystander effects by low dose, low-LET ionizing radiation and discusses how they may be related to observed adaptive responses or other protective effects of low dose exposures. Bystander effects appear to be the result of a generalized stress response in tissues or cells. The signals may be produced by all exposed cells, but the response appears to require a quorum in order to be expressed. The major response involving low LET radiation exposure discussed in the existing literature is a death response. This has many characteristics of apoptosis but is p53 independent. While a death response might appear to be adverse, the position is argued in this paper that it is in fact protective and removes damaged cells from the population. Since many cell populations carry damaged cells without being exposed to radiation, so called "background damage", it is possible that low doses exposures cause removal of cells damaged by agents other than the test dose of radiation. This mechanism would lead to the production of "U-shaped" dose response curves. In this scenario, the level of "adaptive" or beneficial response will be related to the background damage carried by the cell population. This model may be important when attempting to predict the consequences of mixed exposures involving radiation and other environmental stressors.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.