ArticleDose-response : a publication of International Hormesis Society2007
Extremely low doses of X-radiation can induce adaptive responses in mouse prostate.
Article in Dose-response : a publication of International Hormesis Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Low Radiation Environment Switches the Overgrowth-Induced Cell Apoptosis Toward Autophagy.Frontiers in public health · 2020Article
- Dose and Radioadaptive Response Analysis of Micronucleus Induction in Mouse Bone Marrow.International journal of molecular sciences · 2016Article
- Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis.International journal of radiation biology · 2014Article
- Non-linear adaptive phenomena which decrease the risk of infection after pre-exposure to radiofrequency radiation.Dose-response : a publication of International Hormesis Society · 2014Article
- Human Lung Cancer Risks from Radon - Part II - Influence from Combined Adaptive Response and Bystander Effects - A Microdose Analysis.Dose-response : a publication of International Hormesis Society · 2011Article
- A perspective on the scientific, philosophical, and policy dimensions of hormesis.Dose-response : a publication of International Hormesis Society · 2009Article
- Adaptive Response: A Scoping Review of Its Implications in Medicine, Space Exploration, and Beyond.Dose-response : a publication of International Hormesis SocietyReview
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Authors and funding
6 authors.
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Abstract
The pKZ1 mouse chromosomal inversion assay is the only assay that has detected modulation of a mutagenic endpoint after single whole body X-irradiation with doses lower than 1 mGy. A non-linear dose response for chromosomal inversion has been observed in spleen and prostate between 0.001 mGy and 10 mGy, with doses between 0.005-0.01 mGy causing an increase in inversions and doses between 1-10 mGy causing a reduction below spontaneous inversion frequency. An adaptive response is a decreased biological effect induced by a low radiation dose. Adaptive responses contradict the linear-no-threshold model of risk estimation. We demonstrated that very low (0.001 mGy, 0.01 mGy, 1 mGy and 10 mGy) doses of X-radiation induced a chromosomal inversion adaptive response as measured by a reduction in the frequency of subsequent high dose (1000 mGy) induced inversions in prostate. These are the lowest X-radiation doses reported to induce an adaptive response for any endpoint. Adaptive response experiments were also performed where the high dose was administered four hours prior to a low dose of 0.01 mGy or 10 mGy In both cases an adaptive response was observed. Identification of the modifying factors involved in the adaptive response may provide candidates for radioprotection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.