ArticlePLoS genetics2008
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Association between polymorphism in TRAF1/C5 gene and risk of rheumatoid arthritis: a meta-analysis.Molecular biology reports · 2014Pooled it
- The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets.Arthritis research & therapy · 2009Pooled it
- Article
- Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis.Inflammation and regeneration · 2024Article
- A genome-wide cross-trait analysis identifies genomic correlation, pleiotropic loci, and causal relationship between sex hormone-binding globulin and rheumatoid arthritis.Human genomics · 2023Observational
- Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer.Journal of experimental & clinical cancer research : CR · 2021Review
- Inhibitory feedback control of NF-κB signalling in health and disease.The Biochemical journal · 2021Review
- Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis.Calcified tissue international · 2021Article
- C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease.Pharmacogenomics and personalized medicine · 2021Article
- TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection.Cell communication and signaling : CCS · 2020Article
- Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.Journal of advanced research · 2019Article
- Associations ofCentral-European journal of immunology · 2019Article
- Systematic approach demonstrates enrichment of multiple interactions between non-Annals of the rheumatic diseases · 2018Article
- TRAF molecules in inflammation and inflammatory diseases.Current pharmacology reports · 2018Article
- Transcription factor Phf19 positively regulates germinal center reactions that underlies its role in rheumatoid arthritis.American journal of translational research · 2018Article
- TRAF1 Signaling in Human Health and Disease.Frontiers in immunology · 2018Review
- TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions.Nucleic acids research · 2017Article
- The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.Nature immunology · 2017Article
- Association of Complement C5 Gene Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Han Population.PloS one · 2016Article
- The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem.Frontiers in genetics · 2016Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22, these markers do not fully account for the observed heritability. To identify additional susceptibility loci, we carried out a multi-tiered, case-control association study, genotyping 25,966 putative functional SNPs in 475 white North American RA patients and 475 matched controls. Significant markers were genotyped in two additional, independent, white case-control sample sets (661 cases/1322 controls from North America and 596 cases/705 controls from The Netherlands) identifying a SNP, rs1953126, on chromosome 9q33.2 that was significantly associated with RA (OR(common) = 1.28, trend P(comb) = 1.45E-06). Through a comprehensive fine-scale-mapping SNP-selection procedure, 137 additional SNPs in a 668 kb region from MEGF9 to STOM on 9q33.2 were chosen for follow-up genotyping in a staged-approach. Significant single marker results (P(comb)<0.01) spanned a large 525 kb region from FBXW2 to GSN. However, a variety of analyses identified SNPs in a 70 kb region extending from the third intron of PHF19 across TRAF1 into the TRAF1-C5 intergenic region, but excluding the C5 coding region, as the most interesting (trend P(comb): 1.45E-06 --> 5.41E-09). The observed association patterns for these SNPs had heightened statistical significance and a higher degree of consistency across sample sets. In addition, the allele frequencies for these SNPs displayed reduced variability between control groups when compared to other SNPs. Lastly, in combination with the other two known genetic risk factors, HLA-DRB1 and PTPN22, the variants reported here generate more than a 45-fold RA-risk differential.
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Registered trials
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