ArticleAnesthesiology2008
Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies.
Article in Anesthesiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease.Anesthesia and analgesia · 2009Guideline
- Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review.Journal of neuroinflammation · 2024Review
- Comparison of Propofol and Sevoflurane Anaesthesia in Terms of Postoperative Nausea-Vomiting Complication in Cardiac Surgery Patients Undergoing Enhanced Recovery After Surgery Protocol: A Prospective Randomized Study.Turkish journal of anaesthesiology and reanimation · 2024Article
- Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology.Experimental and therapeutic medicine · 2024Article
- Effect of General Anesthetic Agents on Microglia.Aging and disease · 2024Review
- Latest assessment methods for mitochondrial homeostasis in cognitive diseases.Neural regeneration research · 2024Review
- Stress Pathways Induced by Volatile Anesthetics and Failure of Preconditioning in a Mitochondrial Complex I Mutant.Anesthesiology · 2024Article
- Article
- Current status of sevoflurane anesthesia in association with microglia inflammation and neurodegenerative diseases.Ibrain · 2024Review
- The effect of different anesthetics on the incidence of AKI and AKD after neurosurgical procedures.PloS one · 2024Observational
- Research Advances of Mitochondrial Dysfunction in Perioperative Neurocognitive Disorders.Neurochemical research · 2023Review
- Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs.Frontiers in neuroscience · 2023Review
- Editorial: Anesthetic-induced neurotoxicity and neurocognitive impairment of vulnerable brains.Frontiers in aging neuroscience · 2023Article
- Anesthetics and Cell-Cell Communication: Potential CaInternational journal of molecular sciences · 2022Review
- Neonatal Anesthesia and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Effects of general anaesthesia with an inhalational anaesthetic agent on the expression of exosomes in rats.International journal of medical sciences · 2022Article
- Sevoflurane exposure causes neuronal apoptosis and cognitive dysfunction by inducing ER stressFrontiers in aging neuroscience · 2022Article
- Dexmedetomidine Combined with Low-Dose Propofol Declines Learning and Memory Impairment and Neural Cell Injury in Developing Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Early Development of the GABAergic System and the Associated Risks of Neonatal Anesthesia.International journal of molecular sciences · 2021Review
- Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe authors hypothesized that inhalational anesthetics induced cell damage by causing abnormal calcium release from the endoplasmic reticulum via excessive activation of inositol 1,4,5-trisphosphate (IP3) receptors, with isoflurane having greater potency than sevoflurane or desflurane.
methodsThe authors treated DT40 chicken B lymphocytes with total IP3 receptor knockout or their corresponding wild-type control cells with equipotent exposure to isoflurane, sevoflurane, and desflurane. The authors then determined the degree of cell damage by counting the percentage of annexin V- or propidium iodide-positively stained cells or measuring caspase-3 activity. They also studied the changes of calcium concentrations in the endoplasmic reticulum, cytosol, and mitochondria evoked by equipotent concentrations of isoflurane, sevoflurane, and desflurane in both types of DT40 cells.
resultsProlonged use of 2 minimal alveolar concentration sevoflurane or desflurane (24 h) induced significant cell damage only in DT40 wild-type and not in IP3 receptor total knockout cells, but with significantly less potency than isoflurane. In accord, all three inhalational anesthetics induced significant decrease of calcium concentrations in the endoplasmic reticulum, accompanied by a subsequent significant increase in the cytosol and mitochondrial calcium concentrations only in DT40 wild-type and not in IP3 receptor total knockout cells. Isoflurane treatment showed significantly greater potency of effect than sevoflurane or desflurane.
conclusionInhalational anesthetics may induce cell damage by causing abnormal calcium release from the endoplasmic reticulum via excessive activation of IP3 receptors. Isoflurane has greater potency than sevoflurane or desflurane to cause calcium release from the endoplasmic reticulum and to induce cell damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.