ArticleRNA (New York, N.Y.)2008
On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Phosphoproteomic Landscape of HDLBP: Insights into Function and Disease Associations.International journal of molecular sciences · 2026Article
- The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis.Signal transduction and targeted therapy · 2022Article
- Regulation of closely juxtaposed proto-oncogeneRNA (New York, N.Y.) · 2021Article
- Autism-Associated Vigilin Depletion Impairs DNA Damage Repair.Molecular and cellular biology · 2021Article
- Review
- Vigilin protein Vgl1 is required for heterochromatin-mediated gene silencing inThe Journal of biological chemistry · 2019Article
- Mechanistic Dissection of RNA-Binding Proteins in Regulated Gene Expression at Chromatin Levels.Cold Spring Harbor symposia on quantitative biology · 2019Article
- Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains.The protein journal · 2018Article
- All I's on the RADAR: role of ADAR in gene regulation.FEBS letters · 2018Review
- RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression forG3 (Bethesda, Md.) · 2017Article
- How do ADARs bind RNA? New protein-RNA structures illuminate substrate recognition by the RNA editing ADARs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing.Journal of molecular biology · 2016Review
- A-to-I editing of coding and non-coding RNAs by ADARs.Nature reviews. Molecular cell biology · 2016Review
- Human somatic cell mutagenesis creates genetically tractable sarcomas.Nature genetics · 2014Article
- Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration.Frontiers in genetics · 2012Article
- Article
- Functions and regulation of RNA editing by ADAR deaminases.Annual review of biochemistry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vigilin is an RNA-binding protein localized to both the cytoplasm and the nucleus and has been previously implicated in heterochromatin formation and chromosome segregation. We demonstrate here that the C-terminal domain of human vigilin binds to the histone methyltransferase SUV39H1 in vivo. This association is independent of RNA and maps to a site on vigilin that is not involved in its interaction with several other known protein partners. Cells that express high levels of the C-terminal fragment display chromosome segregation defects, and ChIP analyses show changes in the status of pericentric beta-satellite and rDNA chromatin from heterochromatic to more euchromatic form. Finally, a cell line with inducible expression of the vigilin C-terminal fragment displays inducible alterations in beta-satellite chromatin. These and other results lead us to present a new model for vigilin-mediated, RNA-induced gene silencing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.