ArticleProceedings of the National Academy of Sciences of the United States of America2008
Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration.Proceedings of the National Academy of Sciences of the United States of America · 2008Trial
- Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace.Frontiers in molecular neuroscience · 2022Review
- Neuronal histamine and the memory of emotionally salient events.British journal of pharmacology · 2020Review
- Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Resilience and Vulnerability to Trauma: Early Life Interventions Modulate Aversive Memory Reconsolidation in the Dorsal Hippocampus.Frontiers in molecular neuroscience · 2019Article
- "Special K" Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments.Oxidative medicine and cellular longevity · 2019Article
- Target Proteins in the Dorsal Hippocampal Formation Sustain the Memory-Enhancing and Neuroprotective Effects ofFrontiers in pharmacology · 2018Article
- Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Effects of a Flavonoid-Rich Fraction on the Acquisition and Extinction of Fear Memory: Pharmacological and Molecular Approaches.Frontiers in behavioral neuroscience · 2015Article
- Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats.Psychopharmacology · 2014Article
- Low glucose utilization and neurodegenerative changes caused by sodium fluoride exposure in rat's developmental brain.Neuromolecular medicine · 2014Article
- Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments.Experimental gerontology · 2013Article
- Participation of microRNA 124-CREB pathway: a parallel memory enhancing mechanism of standardised extract of Bacopa monniera (BESEB CDRI-08).Neurochemical research · 2012Article
- Posterior parietal cortex and long-term memory: some data from laboratory animals.Frontiers in integrative neuroscience · 2012Article
- II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus.Brain research · 2011Article
- Profile of Ivan Izquierdo.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Perinatal nutritional iron deficiency impairs noradrenergic-mediated synaptic efficacy in the CA1 area of rat hippocampus.The Journal of nutrition · 2010Article
- Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is abundant literature on the role of the basolateral amygdala (BLA) and the CA1 region of the hippocampus in memory formation of inhibitory avoidance (IA) and other behaviorally arousing tasks. Here, we investigate molecular correlates of IA consolidation in the two structures and their relation to NMDA receptors (NMDArs) and beta-adrenergic receptors (beta-ADrs). The separate posttraining administration of antagonists of NMDAr and beta-ADr to BLA and CA1 is amnesic. IA training is followed by an increase of the phosphorylation of calcium and calmodulin-dependent protein kinase II (CaMKII) and ERK2 in CA1 but only an increase of the phosphorylation of ERK2 in BLA. The changes are blocked by NMDAr antagonists but not beta-ADr antagonists in CA1, and they are blocked by beta-ADr but not NMDAr antagonists in BLA. In addition, the changes are accompanied by increased phosphorylation of tyrosine hydroxylase in BLA but not in CA1, suggesting that beta-AD modulation results from local catecholamine synthesis in the former but not in the latter structure. NMDAr blockers in CA1 do not alter the learning-induced neurochemical changes in BLA, and beta-ADr blockade in BLA does not hinder those in CA1. When put together with other data from the literature, the present findings suggest that CA1 and BLA play a role in consolidation, but they operate to an extent in parallel, suggesting that each is probably involved with different aspects of the task studied.
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