ArticleThe Journal of clinical endocrinology and metabolism2008
A genome-wide linkage scan for age at menarche in three populations of European descent.
Article in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility.International journal of molecular sciences · 2021Review
- Article
- Life History Transitions at the Origins of Agriculture: A Model for Understanding How Niche Construction Impacts Human Growth, Demography and Health.Frontiers in endocrinology · 2020Review
- Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls.BMC endocrine disorders · 2018Article
- Age at menarche and age at natural menopause in East Asian women: a genome-wide association study.Age (Dordrecht, Netherlands) · 2016Article
- Gene-environment dependence creates spurious gene-environment interaction.American journal of human genetics · 2014Article
- Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.Human genetics · 2014Article
- Article
- Article
- Genome-wide copy number variation association analyses for age at menarche.The Journal of clinical endocrinology and metabolism · 2012Article
- ApoE genotypes are associated with age at natural menopause in Chinese females.Age (Dordrecht, Netherlands) · 2012Article
- Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.Human molecular genetics · 2012Article
- Genetic determinants of pubertal timing in the general population.Molecular and cellular endocrinology · 2010Review
- Association weight matrix for the genetic dissection of puberty in beef cattle.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.Nature genetics · 2009Article
- Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.Nature genetics · 2009Article
- Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche.PLoS genetics · 2009Article
- Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women.Menopause (New York, N.Y.)Article
- TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women.Menopause (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
contextAge at menarche (AAM) is an important trait both biologically and socially, a clearly defined event in female pubertal development, and has been associated with many clinically significant phenotypes.
objectiveThe objective of the study was to identify genetic loci influencing variation in AAM in large population-based samples from three countries. DESIGN/
participantsRecalled AAM data were collected from 13,697 individuals and 4,899 pseudoindependent sister-pairs from three different populations (Australia, The Netherlands, and the United Kingdom) by mailed questionnaire or interview. Genome-wide variance components linkage analysis was implemented on each sample individually and in combination.
resultsThe mean, sd, and heritability of AAM across the three samples was 13.1 yr, 1.5 yr, and 0.69, respectively. No loci were detected that reached genome-wide significance in the combined analysis, but a suggestive locus was detected on chromosome 12 (logarithm of the odds = 2.0). Three loci of suggestive significance were seen in the U.K. sample on chromosomes 1, 4, and 18 (logarithm of the odds = 2.4, 2.2 and 3.2, respectively).
conclusionsThere was no evidence for common highly penetrant variants influencing AAM. Linkage and association suggest that one trait locus for AAM is located on chromosome 12, but further studies are required to replicate these results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.