ArticleClinical and experimental immunology2008
Appearance of B220low autoantibody-producing B-1 cells at neonatal and older stages in mice.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
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- Splenic B1 B Cells Acquire a Proliferative and Anti-Inflamatory Profile During Pregnancy in Mice.Frontiers in immunology · 2022Article
- Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies.Life science alliance · 2021Article
- Isoflavone daidzein regulates immune responses in the B6C3F1 and non-obese diabetic (NOD) mice.International immunopharmacology · 2019Article
- Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely agingJournal of leukocyte biology · 2017Article
- Liver-inherent immune system: its role in blood-stage malaria.Frontiers in microbiology · 2014Article
- Article
- Biology of autoreactive extrathymic T cells and B-1 cells of the innate immune system.Immunologic research · 2012Review
- Coincidence of autoantibody production with the activation of natural killer T cells in α-galactosylceramide-mediated hepatic injury.Immunology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, normal adult mice carried B220(high) conventional B cells in the spleen and liver, but carried both B220(high) and B220(low) in the bone marrow. However, at the neonatal stage, only B220(low) unconventional B cells were found in all these organs. This pattern continued up to 2 weeks after birth, and at this stage autoantibodies were detected in the sera. This phenomenon was seen in all tested young mice (1-2 weeks), irrespective of their gender. Furthermore, at older stages (more than 20 weeks), B220(low) cells reappeared in the spleen and liver, and these B220(low) cells became dominant in the bone marrow. Autoantibodies also reappeared in the sera of these older mice. Cell-sorting experiments revealed that B220(low) cells were able to produce autoantibodies upon lipopolysaccharide stimuli in vitro. These results suggest that B220(low) cells appear at both neonatal and older stages as physiological responses and eventually produce autoantibodies.
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