SynthesisThe Cochrane database of systematic reviews2008
Influenza vaccines for preventing coronary heart disease.
Synthesis in The Cochrane database of systematic reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Influenza Vaccine to Prevent Adverse Vascular Events: A Pilot Study
A Randomized Controlled Trial of Influenza Vaccine to Prevent Adverse Vascular Events
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics - a systematic literature review.Influenza and other respiratory viruses · 2016Pooled it
- Influenza vaccines may protect against cardiovascular diseases: The evidence is mounting and should be known by the Canadian public health community.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023Article
- Prevalence and prognostic implications of myocardial injury in patients with influenza.European heart journal open · 2022Article
- Randomized controlled trial of influenza vaccine in patients with heart failure to reduce adverse vascular events (IVVE): Rationale and design.American heart journal · 2019Article
- Article
- Technical guidelines for the application of seasonal influenza vaccine in China (2014-2015).Human vaccines & immunotherapeutics · 2015Article
- Cardiac complications of influenza infection in 3 adults.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Article
- Family doctor responses to changes in incentives for influenza immunization under the U.K. Quality and Outcomes Framework pay-for-performance scheme.Health services research · 2012Article
- What components of chronic care organisation relate to better primary care for coronary heart disease patients? An observational study.BMJ open · 2012Article
- Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010Article
- Influenza vaccination in north Indian patients with heart failure.Indian heart journalArticle
- Review
Corrections and comments
- Updated by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVaccination against influenza may reduce the risk of coronary heart disease. However the evidence is scarce and the size of the benefit is unknown.
objectivesTo assess the potential benefit of influenza vaccination for primary and secondary prevention of coronary heart disease. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials, Issue 4 2007, MEDLINE (2005 to January 2008) and EMBASE (2005 to January 2008). Furthermore, we searched databases for recent or ongoing trials and reference lists of articles. Lastly, we contacted pharmaceutical companies for non published data or trials on influenza vaccination. No language restrictions were applied. SELECTION CRITERIA: Randomised clinical trials of influenza vaccination compared to placebo or no treatment in primary or secondary prevention with outcome on coronary heart disease. DATA COLLECTION AND ANALYSIS: Data extraction and the assessment of quality was done with a predefined form by two review authors independently. We contacted investigators when data on the outcome were missing. MAIN
resultsIn the two included trials, 778 participants were randomised to vaccination or placebo. Only 39 participants died a cardiovascular death. In addition, only 35 participants had an acute myocardial infarction. Consequently, estimates of treatment effects were imprecise. AUTHORS'
conclusionsDespite the significant effect noted in the studies, we concluded that there are not enough data to evaluate the effect of vaccination on coronary heart disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.