Evidence map›Paper›PMID 18645635›Full record

ArticleThe Analyst2008

Microarray methods for protein biomarker detection.

Hye Jin Lee, Alastair W Wark, Robert M Corn

Abstract read
In one paragraph

Article in The Analyst, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hye Jin LeeDepartment of Chemistry, Kyungpook National University, Daegu 702-701, South Korea. hyejinlee@knu.ac.kr
Alastair W Wark
Robert M Corn

Funding

SPR IMAGING STUDIES OF PROTEIN/DNA INTERACTIONSR01GM059622 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI CORN, ROBERT M · 1999 to 2018
$5.1M
NIGMS NIH HHS 2R01 GM059622-08NIGMS NIH HHS R01 GM059622
6 · The paper itself

Abstract

The application of protein biomarkers as an aid for the detection and treatment of diseases has been subject to intensified interest in recent years. The quantitative assaying of protein biomarkers in easily obtainable biological fluids such as serum and urine offers the opportunity to improve patient care via earlier and more accurate diagnoses in a convenient, non-invasive manner as well as providing a potential route towards more individually targeted treatment. Essential to achieving progress in biomarker technology is the ability to screen large numbers of proteins simultaneously in a single experiment with high sensitivity and selectivity. In this article, we highlight recent progress in the use of microarrays for high-throughput biomarker profiling and discuss some of the challenges associated with these efforts.

Indexed as

Protein Array AnalysisBiomarkersComputational BiologyGene Expression ProfilingHumansProteinsProteomicsBiomarkersProteins

Identifiers

PMID18645635
PMCPMC2738748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.