ReviewReviews in neurological diseases2008
Virchow's triad: the vascular basis of cerebral injury.
Review in Reviews in neurological diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Construction and Applicability Scenarios of 3D Neurovascular Unit Models In Vitro.Biomolecules · 2026Review
- Outcomes after total shoulder arthroplasty in obstructive sleep apnea patients: a retrospective cohort analysis of over 10,000 patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Rapid Glass-Substrate Digital Light 3D Printing Enables Anatomically Accurate Stroke Patient-Specific Carotid Artery-on-Chips for Personalized Thrombosis Investigation.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Article
- A Novel Human Anti-FV mAb as a Potential Tool for Diagnostic and Coagulation Inhibitory Approaches.International journal of molecular sciences · 2025Article
- The Modified Risk of Paradoxical Embolism Score Is Associated with Patent Foramen Ovale in Patients with Ischemic Stroke: A Nationwide US Analysis.Journal of cardiovascular development and disease · 2024Article
- Combining atomic force microscopy and fluorescence-based techniques to explore mechanical properties of naive and ischemia-affected brain regions in mice.Scientific reports · 2023Article
- Article
- Association of concomitant headache with hypoperfusion in ischemic stroke: A multimodal CT-based study.Clinical and translational science · 2022Article
- Review
- Article
- Coronary Microvascular Dysfunction.Journal of clinical medicine · 2020Review
- Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Histopathological study of encephalomalacia in neonatal calves and application of neuronal and axonal degeneration marker.The Journal of veterinary medical science · 2018Article
- Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages.Frontiers in cellular neuroscience · 2018Article
- Article
- Computed tomography perfusion and computed tomography angiography for prediction of clinical outcomes in ischemic stroke patients after thrombolysis.Neural regeneration research · 2017Article
- Recanalization and Reperfusion in Acute Stroke - More Often Different than Alike.Clinical neuroradiology · 2016Article
- SOD1 nanozyme salvages ischemic brain by locally protecting cerebral vasculature.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia.Journal of visualized experiments : JoVE · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Both the large arteries and microvascular beds of the central nervous system respond to injury by initiating processes compatible with Virchow's triad: alterations in the microvascular permeability barrier, reduction in flow with the target bed, and/or thrombosis of brain-supplying arteries and of the microvasculature. This is particularly true during focal cerebral ischemia. The temporal and topographical coincidence of neuron injury and microvessel response during focal ischemia has suggested that neuron-microvessel interactions could be bidirectional. The neurovascular unit offers a conceptual and structural framework with which to examine events within the microvasculature and their impact on neuron integrity, with the participation of the intervening astrocytes, matrix, and other supportive cells (eg, pericytes and oligodendroglia). Activation of the endothelium and of coagulation, capture of leukocytes, and increased microvessel permeability lead to the focal "no-reflow" phenomenon. Decreased shear stress is a component of the evolving ischemia. Strategies that inhibit the interactions within the microvasculature have been shown to prevent no-reflow and improve neurological outcome. It is, therefore, possible that addressing the processes of Virchow's triad in the setting of focal ischemia could promote neurovascular function.
Indexed as
Identifiers
18645567PMC2693906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.