ArticleProceedings of the National Academy of Sciences of the United States of America2008
Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Multi-omics and electrophysiological examination of GABAMolecular psychiatry · 2026Article
- Regional correlates of tau pathology and synaptic function in primary age-related tauopathy.Journal of Alzheimer's disease : JAD · 2026Article
- Selective vulnerability of human synapses to soluble tau oligomers.Journal of Alzheimer's disease : JAD · 2026Article
- Review
- Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies.Journal of visualized experiments : JoVE · 2022Article
- Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease.Nature communications · 2021Article
- Xenopus leads the way: Frogs as a pioneering model to understand the human brain.Genesis (New York, N.Y. : 2000) · 2021Review
- Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development.Biomarkers in neuropsychiatry · 2020Article
- Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.Scientific reports · 2020Article
- Using Xenopus oocytes in neurological disease drug discovery.Expert opinion on drug discovery · 2020Review
- Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers.Journal of Alzheimer's disease : JAD · 2020Article
- Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABATranslational psychiatry · 2019Article
- Xenbase: Facilitating the Use ofFrontiers in physiology · 2019Review
- Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.Scientific reports · 2016Article
- Loss of functional GABA(A) receptors in the Alzheimer diseased brain.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility.BMC research notes · 2011Article
- Microtransplantation of acetylcholine receptors from normal or denervated rat skeletal muscles to frog oocytes.The Journal of physiology · 2011Article
- Using fluorometry and ion-sensitive microelectrodes to study the functional expression of heterologously-expressed ion channels and transporters in Xenopus oocytes.Methods (San Diego, Calif.) · 2010Review
- Animal models of autism spectrum disorders: information for neurotoxicologists.Neurotoxicology · 2009Article
- A Rosetta stone for analysis of human membrane protein function.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is a complex disorder that arises from the pervasive action of genetic and epigenetic factors that alter synaptic connectivity of the brain. Although GABA and glutamate receptors seem to be two of those factors, very little is known about the functional properties of the autistic receptors. Autistic tissue samples stored in brain banks usually have relatively long postmortem times, and it is highly desirable to know whether neurotransmitter receptors in such tissues are still functional. Here we demonstrate that native receptors microtransplanted from autistic brains, as well as de novo mRNA-expressed receptors, are still functional and susceptible to detailed electrophysiological characterization even after long postmortem intervals. The opportunity to study the properties of human receptors present in diseased brains not only opens new avenues toward understanding autism and other neurological disorders, but it also makes the microtransplantation method a useful translational system to evaluate and develop novel medicinal drugs.
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