ArticleMolecular cancer research : MCR2008
Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition.
Article in Molecular cancer research : MCR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- AU-rich element-binding proteins in colorectal cancer.World journal of gastrointestinal oncology · 2019Review
- Post-transcriptional regulation of cytokine and growth factor signaling in cancer.Cytokine & growth factor reviews · 2017Review
- Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hallmarks of cancer and AU-rich elements.Wiley interdisciplinary reviews. RNA · 2017Review
- Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.Oncotarget · 2016Article
- Comparison of Nanostring nCounter® Data on FFPE Colon Cancer Samples and Affymetrix Microarray Data on Matched Frozen Tissues.PloS one · 2016Article
- Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells.Biomolecules · 2015Article
- Post-transcriptional control of cytokine gene expression in health and disease.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Article
- Transforming growth factor β regulates P-body formation through induction of the mRNA decay factor tristetraprolin.Molecular and cellular biology · 2014Article
- The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.Oncogene · 2013Article
- Mechanistic aspects of COX-2 expression in colorectal neoplasia.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2013Review
- Article
- Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- BRCA1/p220 loss triggers BRCA1-IRIS overexpression via mRNA stabilization in breast cancer cells.Oncotarget · 2012Article
- Article
- The role of tristetraprolin in cancer and inflammation.Frontiers in bioscience (Landmark edition) · 2012Review
- The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.Molecular cancer research : MCR · 2012Article
- Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.Cellular and molecular life sciences : CMLS · 2010Review
- Posttranscriptional Regulation of Cyclooxygenase 2 Expression in Colorectal Cancer.Current colorectal cancer reports · 2010Article
- The role of caveolin-1 in prostate cancer: clinical implications.Prostate cancer and prostatic diseases · 2010Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Colon cancer progression is characterized by activating mutations in Ras and by the emergence of the tumor-promoting effects of transforming growth factor-beta (TGF-beta) signaling. Ras-inducible rat intestinal epithelial cells (RIE:iRas) undergo a well-described epithelial to mesenchymal transition and invasive phenotype in response to H-RasV12 expression and TGF-beta treatment, modeling tumor progression. We characterized global gene expression profiles accompanying Ras-induced and TGF-beta-induced epithelial to mesenchymal transition in RIE:iRas cells by microarray analysis and found that the regulation of gene expression by the combined activation of Ras and TGF-beta signaling was associated with enrichment of a class of mRNAs containing 3' AU-rich element (ARE) motifs known to regulate mRNA stability. Regulation of ARE-containing mRNA transcripts was validated at the mRNA level, including genes important for tumor progression. Ras and TGF-beta synergistically increased the expression and mRNA stability of vascular endothelial growth factor (VEGF), a key regulator of tumor angiogenesis, in both RIE:iRas cells and an independent cell culture model (young adult mouse colonocyte). Expression profiling of human colorectal cancers (CRC) further revealed that many of these genes, including VEGF and PAI-1, were differentially expressed in stage IV human colon adenocarcinomas compared with adenomas. Furthermore, genes differentially expressed in CRC are also significantly enriched with ARE-containing transcripts. These studies show that oncogenic Ras and TGF-beta synergistically regulate genes containing AREs in cultured rodent intestinal epithelial cells and suggest that posttranscriptional regulation of gene expression is an important mechanism involved in cellular transformation and CRC tumor progression.
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Registered trials
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