ArticleThe Journal of cell biology2008
Spindle checkpoint activation at meiosis I advances anaphase II onset via meiosis-specific APC/C regulation.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast.Genome biology · 2025Article
- Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition.iScience · 2023Article
- Exploring Plant Meiosis: Insights from the Kinetochore Perspective.Current issues in molecular biology · 2023Review
- Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I.Open biology · 2021Article
- A visual atlas of meiotic protein dynamics in living fission yeast.Open biology · 2021Article
- Tell the Difference Between Mitosis and Meiosis: Interplay Between Chromosomes, Cytoskeleton, and Cell Cycle Regulation.Frontiers in cell and developmental biology · 2021Review
- Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.The Journal of biological chemistry · 2020Article
- Meiosis-Specific Functions of Kinesin Motors in Cohesin Removal and Maintenance of Chromosome Integrity in Budding Yeast.Molecular and cellular biology · 2020Article
- Random chromosome distribution in the first meiosis of F1 disomic substitution line 2R(2D) x rye hybrids (ABDR, 4× = 28) occurs without bipolar spindle assembly.Comparative cytogenetics · 2020Article
- The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast.Cell discovery · 2017Article
- Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly.The Journal of cell biology · 2015Article
- The spindle checkpoint and chromosome segregation in meiosis.The FEBS journal · 2015Review
- Chromosome segregation in plant meiosis.Frontiers in plant science · 2014Review
- Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation.Nature cell biology · 2013Article
- Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle.EMBO reports · 2013Article
- Microtubule-organizing center formation at telomeres induces meiotic telomere clustering.The Journal of cell biology · 2013Article
- Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.Molecular biology of the cell · 2011Article
- Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I.PLoS genetics · 2011Article
- Article
- The consequences of asynapsis for mammalian meiosis.Nature reviews. Genetics · 2009Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mitosis, the spindle assembly checkpoint (SAC) inhibits the Cdc20-activated anaphase-promoting complex/cyclosome (APC/C(Cdc20)), which promotes protein degradation, and delays anaphase onset to ensure accurate chromosome segregation. However, the SAC function in meiotic anaphase regulation is poorly understood. Here, we examined the SAC function in fission yeast meiosis. As in mitosis, a SAC factor, Mad2, delayed anaphase onset via Slp1 (fission yeast Cdc20) when chromosomes attach to the spindle improperly. However, when the SAC delayed anaphase I, the interval between meiosis I and II shortened. Furthermore, anaphase onset was advanced and the SAC effect was reduced at meiosis II. The advancement of anaphase onset depended on a meiosis-specific, Cdc20-related factor, Fzr1/Mfr1, which contributed to anaphase cyclin decline and anaphase onset and was inefficiently inhibited by the SAC. Our findings show that impacts of SAC activation are not confined to a single division at meiosis due to meiosis-specific APC/C regulation, which has probably been evolved for execution of two meiotic divisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.