ArticleMolecular and cellular biology2008
Deficiency of Mbd2 attenuates Wnt signaling.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition.Experimental & molecular medicine · 2024Article
- LECT2 Protects Nile Tilapia (Frontiers in immunology · 2021Article
- Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell Plasticity.Stem cell reviews and reports · 2020Review
- A robust twelve-gene signature for prognosis prediction of hepatocellular carcinoma.Cancer cell international · 2020Article
- DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications.Frontiers in oncology · 2019Review
- Article
- Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.The Journal of pathology · 2018Article
- Reduced MBD2 expression enhances airway inflammation in bronchial epithelium in COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.Carcinogenesis · 2017Review
- Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulationDisease models & mechanisms · 2017Article
- Leukocyte Cell-Derived Chemotaxin-2: It's Role in Pathophysiology and Future in Clinical Medicine.Clinical and translational science · 2017Review
- Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells.Oncogene · 2016Article
- Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold.The Journal of biological chemistry · 2016Article
- Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions.Epigenomics · 2016Article
- Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation.Frontiers in genetics · 2016Review
- Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.Nucleic acids research · 2015Article
- Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.Carcinogenesis · 2014Article
- Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.PLoS genetics · 2014Article
- The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.Oncogene · 2014Article
- ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.Cell stem cell · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We have previously shown that deficiency of the methyl binding domain protein Mbd2 dramatically reduces adenoma burden on an Apc(Min/+) background. To investigate the mechanism underlying this phenomenon, we have determined the effect of Mbd2 deficiency upon the phenotypes imposed by the conditional deletion of Apc in the small intestine. Microarray analysis demonstrated a partial suppression of the Wnt pathway in the absence of Mbd2. Mbd2 deficiency also influenced one immediate cellular consequence of Apc loss, with normalization of Paneth cell positioning. From a mechanistic perspective, we show that deficiency of Mbd2 elevates levels of the known Wnt target Lect2, and we confirm here that Mbd2 binds the Lect2 promoter in association with NuRD. Furthermore, we show that Lect2 is capable of functioning as a Wnt pathway repressor. These results therefore provide a mechanistic basis for the epigenetic control of adenoma formation mediated through Mbd2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.