ArticleMolecular and cellular biology2008
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Circulating PBX1 and age-related sarcopenia phenotypes: metabolic mediation analyses in a community-based study.European geriatric medicine · 2026Article
- Resveratrol Improves Endothelial Function by A PREP1-Mediated Pathway in Mouse Aortic Endothelial Cells.International journal of molecular sciences · 2023Article
- Leptin and TGF-β1 Downregulate PREP1 Expression in Human Adipose-Derived Mesenchymal Stem Cells and Mature Adipocytes.Frontiers in cell and developmental biology · 2021Article
- The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness.Cancers · 2020Review
- The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells.International journal of molecular sciences · 2019Article
- c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.Molecular oncology · 2019Article
- Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells.International journal of molecular sciences · 2019Review
- MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling.Journal of cellular and molecular medicine · 2018Article
- Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.Molecular neurobiology · 2018Article
- Prep1, A Homeodomain Transcription Factor Involved in Glucose and Lipid Metabolism.Frontiers in endocrinology · 2018Review
- A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.Oncotarget · 2017Article
- The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability.Molecular biotechnology · 2016Article
- Transcriptional control of insulin-sensitive glucose carrier Glut4 expression in adipose tissue cells.Doklady. Biochemistry and biophysics · 2016Article
- Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle.Diabetologia · 2016Article
- Article
- Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle.Molecular and cellular biology · 2014Article
- Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.Diabetologia · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance. In addition, these mice exhibit protection from streptozotocin-induced diabetes and enhanced insulin sensitivity with improved glucose uptake and insulin-dependent glucose disposal by skeletal muscle. This muscle phenotype does not depend on reduced expression of the known Prep1 transcription partner, Pbx1. Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160. Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle. Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1. In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype. Finally, we show that Prep1 controls the stability of the p160 protein. We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.