ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2008
The improvement of renal survival with steroid pulse therapy in IgA nephropathy.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Efficacy and safety of steroids glucocorticoids compared with supportive therapy for IgA nephropathy: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- Steroids in the treatment of IgA nephropathy to the improvement of renal survival: a systematic review and meta-analysis.PloS one · 2011Pooled it
- Comparison of steroid-pulse therapy and combined with mizoribine in IgA nephropathy: a randomized controlled trial.Clinical and experimental nephrology · 2016Trial
- Pathological sub-analysis of a multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy versus steroid pulse monotherapy in patients with immunoglobulin A nephropathy.Clinical and experimental nephrology · 2016Trial
- Comparative analysis between the safety and efficacy of oral corticosteroids versus corticosteroids pulse therapies in IgA nephropathy.Renal failure · 2023Article
- Management of IgA Vasculitis with Nephritis.Paediatric drugs · 2021Review
- Estimated plasma osmolarity and risk of end-stage kidney disease in patients with IgA nephropathy.Clinical and experimental nephrology · 2020Article
- Comprehensive evaluation of the significance of immunofluorescent findings on clinicopathological features in IgA nephropathy.Clinical and experimental nephrology · 2019Article
- Clinical outcomes in children with Henoch-Schönlein purpura nephritis without crescents.Pediatric nephrology (Berlin, Germany) · 2017Article
- Reduction of proteinuria by therapeutic intervention improves the renal outcome of elderly patients with IgA nephropathy.Clinical and experimental nephrology · 2016Article
- Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction.ESC heart failure · 2016Article
- The effect of renin-angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy.Clinical and experimental nephrology · 2016Observational
- Immunosuppressive agents versus steroids in the treatment of IgA nephropathy-induced proteinuria: A meta-analysis.Experimental and therapeutic medicine · 2016Article
- Comparison of effective impact among tonsillectomy alone, tonsillectomy combined with oral steroid and with steroid pulse therapy on long-term outcome of immunoglobulin A nephropathy.Clinical and experimental nephrology · 2013Article
- Pathology: Oxford IgA nephropathy classification: valid for children?Nature reviews. Nephrology · 2010Article
- Clinical and histopathological spectrum of IgA nephropathy in Kuwait.Annals of Saudi medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe benefits of steroid therapy in immunoglobulin A nephropathy (IgAN) have not been established.
methodsThe effect of steroids on kidney survival was retrospectively investigated in 702 patients with IgAN by multivariate analyses.
resultsThere were 295 men and 407 women. The median follow-up period was 62 months. One hundred and ninety-four patients were treated with oral steroids (oral steroid group). Thirty-four patients were treated with methylprednisolone (mPSL) pulse therapy (pulse steroid group) followed by oral prednisolone (PSL). In 474 patients, no steroid was used (no steroid group). The urinary protein-creatinine ratio and histological grade were significantly different among treatment groups and were highest in the pulse steroid group followed by the oral steroid group and lowest in the no steroid patients. Serum creatinine was significantly higher in the pulse steroid group than in other two groups. Eighty-five patients developed end-stage renal failure (ESRF) requiring dialysis. [corrected] In multivariate analysis, steroid pulse therapy significantly decreased the risk of ESRF while oral steroid treatment did not improve renal survival in this cohort.
conclusionWe found that pulse steroid therapy improved kidney survivals in IgAN. Since the clinical findings and histological grade were the most severe in patients treated with mPSL pulse therapy, such therapy may prevent progression of IgAN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.