ArticleJournal of neurochemistry2008
GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
Article in Journal of neurochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Ectopic activation of GABANature ecology & evolution · 2021Article
- Article
- CaMolecular neurobiology · 2019Article
- Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.The Journal of biological chemistry · 2016Article
- Regulation of GPCR Trafficking by Ubiquitin.Progress in molecular biology and translational science · 2015Review
- Receptor trafficking and the regulation of synaptic plasticity by SUMO.Neuromolecular medicine · 2013Review
- Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.The Journal of biological chemistry · 2013Article
- Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation.World journal of biological chemistry · 2012Article
- Neuronal Functions of ESCRTs.Experimental neurobiology · 2012Article
- Shaping development with ESCRTs.Nature cell biology · 2011Review
- Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit.The Journal of biological chemistry · 2011Article
- Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP.Biochemical and biophysical research communications · 2011Article
- Frontotemporal dementia caused by CHMP2B mutations.Current Alzheimer research · 2011Review
- The ESCRT complexes.Critical reviews in biochemistry and molecular biology · 2010Review
- Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.The Journal of biological chemistry · 2010Article
- Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations.Human molecular genetics · 2010Article
- GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation.Neuroscience letters · 2009Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The neuron-specific G protein-coupled receptor interacting scaffold protein (GISP) is a multidomain, brain-specific protein derived from the A-kinase anchoring protein-9 gene. We originally isolated GISP as an interacting partner for the GABA(B) receptor subunit GABA(B1). Here, we show that the protein tumour susceptibility gene 101 (TSG101), an integral component of the endosomal sorting machinery that targets membrane proteins for lysosomal degradation, also interacts with GISP. TSG101 co-immunoprecipitates with GISP from adult rat brain, and using GST pull-downs, we identified that the eighth coiled-coiled region of GISP is critical for TSG101 association. Intriguingly, although there is no direct interaction between GISP and the GABA(B2) subunit, their co-expression in HEK293 cells increases levels of GABA(B2). GISP also inhibits TSG101-dependent GABA(B2) down-regulation in human embryonic kidney 293 cells whereas over-expression of a mutant GISP lacking the TSG101 binding domain has no effect on GABA(B2) degradation. These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.