ArticleHead & neck2008
Molecular signatures of metastasis in head and neck cancer.
Article in Head & neck, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Identification of ovarian cancer metastatic miRNAs.PloS one · 2013Trial
- Mutated HRAS Activates YAP1-AXL Signaling to Drive Metastasis of Head and Neck Cancer.Cancer research · 2023Article
- Article
- Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes.Cancers · 2020Article
- Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancy after pulmonary metastasectomy.Scientific reports · 2019Article
- Article
- Molecular Classification of Lymph Node Metastases Subtypes Predict for Survival in Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Article
- Gene Expression Signatures for Head and Neck Cancer Patient Stratification: Are Results Ready for Clinical Application?Current treatment options in oncology · 2017Review
- Prognostic significance of the tumour-adjacent tissue in head and neck cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma.British journal of cancer · 2014Article
- Prognostic biological features in neck dissection specimens.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Review
- Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse.Oral surgery, oral medicine, oral pathology and oral radiology · 2013Article
- Single sample expression-anchored mechanisms predict survival in head and neck cancer.PLoS computational biology · 2012Article
- Current potential and limitations of molecular diagnostic methods in head and neck cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2010Review
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMetastases are the primary cause of cancer treatment failure and death, yet metastatic mechanisms remain incompletely understood.
methodsWe studied the molecular basis of head and neck cancer metastasis by transcriptionally profiling 70 samples from 27 patients-matching normal adjacent tissue, primary tumor, and cervical lymph node metastases.
resultsWe identified tumor-associated expression signatures common to both primary tumors and metastases. Use of matching metastases revealed an additional 46 dysregulated genes associated solely with head and neck cancer metastasis. However, despite being metastasis-specific in our sample set, these 46 genes are concordant with genes previously discovered in primary tumors that metastasized.
conclusionsAlthough our data and related studies show that most of the metastatic potential appears to be inherent to the primary tumor, they are also consistent with the notion that a limited number of additional clonal changes are necessary to yield the final metastatic cell(s), albeit in a variable temporal order.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.