ArticleHead & neck2008
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
Article in Head & neck, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 15 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 15 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma: a systematic review with five analyses.BMC cancer · 2024Pooled it
- Association ofMedicina (Kaunas, Lithuania) · 2021Pooled it
- Association between MPO-463G > A polymorphism and cancer risk: evidence from 60 case-control studies.World journal of surgical oncology · 2017Pooled it
- Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies.Medicine · 2016Pooled it
- CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.Familial cancer · 2016Pooled it
- CYP2E1 RsaI/PstI polymorphisms contributed to oral cancer susceptibility: a meta-analysis.International journal of clinical and experimental pathology · 2015Pooled it
- Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer.PloS one · 2015Pooled it
- N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Glutathione S-transferase P1 Ile105Val polymorphism and oral cancer risk: a meta-analysis.International journal of medical sciences · 2013Pooled it
- Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Pooled it
- NAT2 polymorphisms with oral carcinoma susceptibility: a meta-analysis.Molecular biology reports · 2012Pooled it
- CYP2E1 Rsa I/Pst I polymorphism contributes to oral cancer susceptibility: a meta-analysis.Molecular biology reports · 2012Pooled it
- Association between GSTM1 and GSTT1 allelic variants and head and neck squamous cell cancinoma.PloS one · 2012Pooled it
- Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer.Molecular biology reports · 2011Pooled it
- The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.BMC cancer · 2010Pooled it
- Evaluation of changes in Salivary Lactate Dehydrogenase Level for detection of Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis Study.International journal of preventive medicine · 2023Review
- Global Scenario of Research in Oral Cancer.Journal of maxillofacial and oral surgery · 2019Review
- Association of Glutathione-S-Transferases M1 and T1 Deletional Variants with Development of Oral Squamous Cell Carcinoma: A Study in the South-East of Iran.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Article
- Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma.Cancer letters · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGenetic variation in xenobiotic metabolizing enzymes may explain differing susceptibilities to the cancer causing effects of tobacco and alcohol.
methodsWe compared 203 oral squamous cell carcinoma cases and 416 controls for single nucleotide polymorphisms (SNPs) in 8 genes (CYP1A1, CYP2E1, MPO, mEH, GSTM1, GSTT1, GSTP1, and NAT2). Except for NAT2, genotype frequencies were similar in the 2 groups. We classified subjects as fast or slow NAT2 acetylators genotyping 13 NAT2 SNPs.
resultsFast acetylators were overrepresented in cases (53.7%) compared with controls (43.9%; odds ratio (OR) 1.55, 95% confidence interval (CI) 1.08-2.20; p value = .03). Gene-gene interaction testing suggested several cancer-NAT2 associations, with association strongest among persons without a CYP1A1 variant (*2C or *4) allele (OR 1.77, 95% CI 1.20-2.60, p value = .03) or with a variant MPO (463A) allele (OR 2.38, 95% CI 1.34-4.21, p value = .05).
conclusionThese results implicate fast NAT2 acetylation as a risk factor for oral cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.