Mutation in TERT separates processivity from anchor-site function.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

39 citing papers in PubMed, 61 citations in OpenAlex.

1. Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle.Nature communications · 2026
   Article
2. Giardia telomeres and telomerase.Parasitology research · 2024
   Review
3. Dynamic folding and accessibility of telomeric overhang.Proceedings of the National Academy of Sciences of the United States of America · 2022
   Article
4. Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes.Biomedicines · 2021
   Review
5. Therapeutic Targets in Telomerase and Telomere Biology of Cancers.Indian journal of clinical biochemistry : IJCB · 2020
   Review
6. Structural biology of telomeres and telomerase.Cellular and molecular life sciences : CMLS · 2020
   Review
7. Structural Biology of Telomerase.Cold Spring Harbor perspectives in biology · 2019
   Review
8. Single-Molecule Analysis of Reverse Transcriptase Enzymes.Cold Spring Harbor perspectives in biology · 2019
   Review
9. Telomere DNA G-quadruplex folding within actively extending human telomerase.Proceedings of the National Academy of Sciences of the United States of America · 2019
   Article
10. Structure of Telomerase with Telomeric DNA.Cell · 2018
    Article
11. Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain.Nucleic acids research · 2018
    Article
12. A single nucleotide incorporation step limits human telomerase repeat addition activity.The EMBO journal · 2018
    Article
13. Progress in Human and Tetrahymena Telomerase Structure Determination.Annual review of biophysics · 2017
    Review
14. Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis.RNA (New York, N.Y.) · 2017
    Article
15. Human telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template.Nucleic acids research · 2016
    Article
16. Structural basis of template-boundary definition in Tetrahymena telomerase.Nature structural & molecular biology · 2015
    Article
17. Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.Science (New York, N.Y.) · 2015
    Article
18. The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.Nucleic acids research · 2015
    Article
19. Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex.The EMBO journal · 2014
    Article
20. A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome.Blood · 2013
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 1 institution in 1 country.

Funding

Abstract

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