Evidence map›Paper›PMID 18641236›Full record

ReviewAmerican journal of physiology. Lung cellular and molecular physiology2008

Pulmonary applications and toxicity of engineered nanoparticles.

Jeffrey W Card, Darryl C Zeldin, James C Bonner, Earle R Nestmann

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Lung cellular and molecular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 304 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Inhalation exposure-induced toxicity and disease mediated via mTOR dysregulation.Experimental biology and medicine (Maywood, N.J.) · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. MicroRNA Targets for Asthma Therapy.Advances in experimental medicine and biology · 2021
    Article
  13. Long-term exposure to a mixture of industrial SOEnvironmental health : a global access science source · 2020
    Article
  14. Article
  15. Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeffrey W CardCantox Health Sciences International, 2233 Argentia Rd., Suite 308, Mississauga, Ontario, Canada L5N 2X7. jcard@cantox.com
Darryl C Zeldin
James C Bonner
Earle R Nestmann
Cantox Health Sciences International · CA

Funding

Alterations In Pulmonary Immune Function And Host Resistance In COX Null MiceZIAES025043 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$11.7M
Therapeutic Strategies for Environmental Lung DiseasesR21ES015801 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BONNER, JAMES CHRISTOPHER · 2007 to 2008
$395k
Intramural NIH HHSNIEHS NIH HHS R21 ES015801-01
6 · The paper itself

Abstract

Because of their unique physicochemical properties, engineered nanoparticles have the potential to significantly impact respiratory research and medicine by means of improving imaging capability and drug delivery, among other applications. These same properties, however, present potential safety concerns, and there is accumulating evidence to suggest that nanoparticles may exert adverse effects on pulmonary structure and function. The respiratory system is susceptible to injury resulting from inhalation of gases, aerosols, and particles, and also from systemic delivery of drugs, chemicals, and other compounds to the lungs via direct cardiac output to the pulmonary arteries. As such, it is a prime target for the possible toxic effects of engineered nanoparticles. The purpose of this article is to provide an overview of the potential usefulness of nanoparticles and nanotechnology in respiratory research and medicine and to highlight important issues and recent data pertaining to nanoparticle-related pulmonary toxicity.

Indexed as

AnimalsDrug Delivery SystemsHumansLungModels, BiologicalNanoparticlesNanotechnologyTissue Distribution

Identifiers

PMID18641236
PMCPMC2536798
OpenAlexW2009217924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.