ArticleBiophysical journal2008
Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Comparing cryo-EM methods and molecular dynamics simulation to investigate heterogeneity in ligand-bound TRPV1.Nature communications · 2025Article
- Structures of closed and open states of a voltage-gated sodium channel.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hinge-bending motions in the pore domain of a bacterial voltage-gated sodium channel.Biochimica et biophysica acta · 2012Article
- A pharmacological analysis of high-affinity sodium transport in barley (Hordeum vulgare L.): a 24Na+/42K+ study.Journal of experimental botany · 2012Article
- Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein.The Journal of biological chemistry · 2011Article
- Article
- Review
- A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data.The Journal of general physiology · 2010Article
- Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels.Proteins · 2010Article
- Motility and chemotaxis in alkaliphilic Bacillus species.Future microbiology · 2009Review
- Subtype-selective targeting of voltage-gated sodium channels.British journal of pharmacology · 2009Review
- Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2.The Journal of biological chemistry · 2009Article
- Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- A molecular model of the inner pore of the Ca channel in its open state.Channels (Austin, Tex.)Article
- Structural and regulatory evolution of cellular electrophysiological systems.Evolution & developmentReview
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Authors and funding
3 authors.
Funding
Abstract
The NaChBac prokaryotic sodium channel appears to be a descendent of an evolutionary link between voltage-gated K(V) and Ca(V) channels. Like K(V) channels, four identical six-transmembrane subunits comprise the NaChBac channel, but its selectivity filter possesses a signature sequence of eukaryotic Ca(V) channels. We developed structural models of the NaChBac channel in closed and open conformations, using K(+)-channel crystal structures as initial templates. Our models were also consistent with numerous experimental results and modeling criteria. This study concerns the pore domain. The major differences between our models and K(+) crystal structures involve the latter portion of the selectivity filter and the bend region in S6 of the open conformation. These NaChBac models may serve as a stepping stone between K(+) channels of known structure and Na(V), Ca(V), and TRP channels of unknown structure.
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