ArticleBiophysical journal2008
Effect of nonuniform interstitial space properties on impulse propagation: a discrete multidomain model.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Efficient, cell-based simulations of cardiac electrophysiology; The Kirchhoff Network Model (KNM).NPJ systems biology and applications · 2023Article
- Ephaptic Coupling Is a Mechanism of Conduction Reserve During Reduced Gap Junction Coupling.Frontiers in physiology · 2022Article
- Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?Frontiers in physiology · 2022Review
- Initiation and entrainment of multicellular automaticity via diffusion limited extracellular domains.Biophysical journal · 2021Article
- Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction.Frontiers in physiology · 2021Article
- Deriving the Bidomain Model of Cardiac Electrophysiology From a Cell-Based Model; Properties and Comparisons.Frontiers in physiology · 2021Article
- From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology.Frontiers in physiology · 2021Article
- Properties of cardiac conduction in a cell-based computational model.PLoS computational biology · 2019Article
- BeatBox-HPC simulation environment for biophysically and anatomically realistic cardiac electrophysiology.PloS one · 2017Article
- Simulation of Ectopic Pacemakers in the Heart: Multiple Ectopic Beats Generated by Reentry inside Fibrotic Regions.BioMed research international · 2015Article
- Microdomain effects on transverse cardiac propagation.Biophysical journal · 2014Article
- Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback.Journal of biomechanical engineering · 2014Review
- Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias.Frontiers in physiology · 2014Review
- Microscopic variations in interstitial and intracellular structure modulate the distribution of conduction delays and block in cardiac tissue with source-load mismatch.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2012Article
- Simulations of complex and microscopic models of cardiac electrophysiology powered by multi-GPU platforms.Computational and mathematical methods in medicine · 2012Article
- Modeling electrical activity of myocardial cells incorporating the effects of ephaptic coupling.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Probing field-induced tissue polarization using transillumination fluorescent imaging.Biophysical journal · 2010Article
- A computer model of engineered cardiac monolayers.Biophysical journal · 2010Article
- Collision-based spiral acceleration in cardiac media: roles of wavefront curvature and excitable gap.Biophysical journal · 2010Article
- Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This work presents a discrete multidomain model that describes ionic diffusion pathways between connected cells and within the interstitium. Unlike classical models of impulse propagation, the intracellular and extracellular spaces are represented as spatially distinct volumes with dynamic/static boundary conditions that electrically couple neighboring spaces. The model is used to investigate the impact of nonuniform geometrical and electrical properties of the interstitial space surrounding a fiber on conduction velocity and action potential waveshape. Comparison of the multidomain and bidomain models shows that although the conduction velocity is relatively insensitive to cases that confine 50% of the membrane surface by narrow extracellular depths (> or =2 nm), the action potential morphology varies greatly around the fiber perimeter, resulting in changes in the magnitude of extracellular potential in the tight spaces. Results also show that when the conductivity of the tight spaces is sufficiently reduced, the membrane adjacent to the tight space is eliminated from participating in propagation, and the conduction velocity increases. Owing to its ability to describe the spatial discontinuity of cardiac microstructure, the discrete multidomain can be used to determine appropriate tissue properties for use in classical macroscopic models such as the bidomain during normal and pathophysiological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.