ArticleMolecular biology and evolution2008
From drought sensing to developmental control: evolution of cyclic AMP signaling in social amoebas.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Lives in a gram of soil: linking life cycle biology to soil ecology.The ISME journal · 2026Review
- Adaptive evolutionary trajectories in complexity: Transitions between unicellularity and facultative differentiated multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia.BMC ecology and evolution · 2023Article
- Bacteria evolve macroscopic multicellularity by the genetic assimilation of phenotypically plastic cell clustering.Nature communications · 2023Article
- Development of the dictyostelid Polysphondylium violaceum does not require secreted cAMP.Biology open · 2023Article
- Co-option of stress mechanisms in the origin of evolutionary novelties.Evolution; international journal of organic evolution · 2022Article
- Autophagy of the somatic stalk cells likely nurses the propagating spores of Dictyostelid social amoebas.Open research Europe · 2022Article
- Novel RNAseq-Informed Cell-type Markers and Their Regulation Alter Paradigms ofFrontiers in cell and developmental biology · 2022Article
- Transcriptional milestones inGenome research · 2021Article
- The Consequences of Budding versus Binary Fission on Adaptation and Aging in Primitive Multicellularity.Genes · 2021Article
- Review
- From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas.BMC genomics · 2019Article
- Emergence of diverse life cycles and life histories at the origin of multicellularity.Nature ecology & evolution · 2019Article
- Evolution of multicellularity in Dictyostelia.The International journal of developmental biology · 2019Review
- Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia.EvoDevo · 2018Article
- The Origin of Animal Multicellularity and Cell Differentiation.Developmental cell · 2017Review
- On the origin of biological construction, with a focus on multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Biological Activity of the Alternative Promoters of the Dictyostelium discoideum Adenylyl Cyclase A Gene.PloS one · 2016Article
- Secreted Cyclic Di-GMP Induces Stalk Cell Differentiation in the Eukaryote Dictyostelium discoideum.Journal of bacteriology · 2016Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Amoebas and other protists commonly encyst when faced with environmental stress. Although little is known of the signaling pathways that mediate encystation, the analogous process of spore formation in dictyostelid social amoebas is better understood. In Dictyostelium discoideum, secreted cyclic AMP (cAMP) mediates the aggregation of starving amoebas and induces the differentiation of prespore cells. Intracellular cAMP acting on cAMP-dependent protein kinase (PKA) triggers the maturation of spores and prevents their germination under the prevalent conditions of high osmolality in the spore head. The osmolyte-activated adenylate cyclase, ACG, produces cAMP for prespore differentiation and inhibition of spore germination. To retrace the origin of ACG function, we investigated ACG gene conservation and function in species that span the dictyostelid phylogeny. ACG genes, osmolyte-activated ACG activity, and osmoregulation of spore germination were detected in species that represent the 4 major groups of Dictyostelia. Unlike the derived species D. discoideum, many basal Dictyostelia have retained the ancestral mechanism of encystation from solitary amoebas. In these species and in solitary amoebas, encystation is independently triggered by starvation or by high osmolality. Osmolyte-induced encystation was accompanied by an increase in cAMP and prevented by inhibition of PKA, indicating that ACG and PKA activation mediate this response. We propose that high osmolality signals drought in soil amoebas and that developmental cAMP signaling in the Dictyostelia has evolved from this stress response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.