ArticleThe Journal of biological chemistry2008
Separate cis-trans pathways post-transcriptionally regulate murine CD154 (CD40 ligand) expression: a novel function for CA repeats in the 3'-untranslated region.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- A Posttranscriptional Pathway of CD40 Ligand mRNA Stability Is Required for the Development of an Optimal Humoral Immune Response.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- A Novel Long Noncoding RNA lincRNA00892 Activates CD4Frontiers in pharmacology · 2021Article
- The 3'-UTR (CA)n microsatellite on CD40LG gene as a possible genetic marker for rheumatoid arthritis in Mexican population: impact on CD40LG mRNA expression.Clinical rheumatology · 2018Article
- Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells.Scientific reports · 2017Article
- PTB and TIAR binding to insulin mRNA 3'- and 5'UTRs; implications for insulin biosynthesis and messenger stability.Heliyon · 2016Article
- Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?Scientific reports · 2014Article
- GRK5 intronic (CA)n polymorphisms associated with type 2 diabetes in Chinese Hainan Island.PloS one · 2014Article
- Post-transcriptional regulatory networks in immunity.Immunological reviews · 2013Review
- Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage.Nucleic acids research · 2011Article
- FUBP3 interacts with FGF9 3' microsatellite and positively regulates FGF9 translation.Nucleic acids research · 2011Article
- Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation.Oncogene · 2011Article
- Post-transcriptional regulons coordinate the initiation and resolution of inflammation.Nature reviews. Immunology · 2010Review
- In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells.European journal of immunology · 2009Article
- Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.Molecular and cellular biology · 2009Article
- Review
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
We report a role for CA repeats in the 3'-untranslated region (3'-UTR) in regulating CD154 expression. Human CD154 is encoded by an unstable mRNA; this instability is conferred in cis by a portion of its 3'-UTR that includes a polypyrimidine-rich region and CA dinucleotide repeat. We demonstrate similar instability activity with the murine CD154 3'-UTR. This instability element mapped solely to a conserved 100-base CU-rich region alone, which we call a CU-rich response element. Surprisingly, the CA dinucleotide-rich region also regulated reporter expression but at the level of translation. This activity was associated with poly(A) tail shortening and regulated by heterogeneous nuclear ribonucleoprotein L levels. We conclude that the CD154 3'-UTR contains dual cis-acting elements, one of which defines a novel function for exonic CA dinucleotide repeats. These findings suggest a mechanism for the association of 3'-UTR CA-rich response element polymorphisms with CD154 overexpression and the subsequent risk of autoimmune disease.
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