ReviewJournal of hepatology2008
The unfinished business of primary biliary cirrhosis.
Review in Journal of hepatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.Hepatology (Baltimore, Md.) · 2015Article
- Article
- Tracing environmental markers of autoimmunity: introducing the infectome.Immunologic research · 2013Review
- Infectome: a platform to trace infectious triggers of autoimmunity.Autoimmunity reviews · 2013Review
- Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.Molecular & cellular proteomics : MCP · 2012Article
- Overcoming a "probable" diagnosis in antimitochondrial antibody negative primary biliary cirrhosis: study of 100 sera and review of the literature.Clinical reviews in allergy & immunology · 2012Review
- Towards systemic sclerosis and away from primary biliary cirrhosis: the case of PTPN22.Auto- immunity highlights · 2012Review
- Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways.PloS one · 2012Article
- Fetomaternal alloimmunity as a cause of liver disease.Auto- immunity highlights · 2011Review
- Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veterans.Cancer · 2011Article
- Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis.Epigenetics · 2011Article
- Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients.World journal of gastroenterology · 2010Article
- Immune-mediated bile duct injury: The case of primary biliary cirrhosis.World journal of gastrointestinal pathophysiology · 2010Article
- Primary biliary cirrhosis: what do autoantibodies tell us?World journal of gastroenterology · 2010Review
- Update on primary biliary cirrhosis.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2010Review
- Experimental evidence on the immunopathogenesis of primary biliary cirrhosis.Cellular & molecular immunology · 2010Review
- Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis.Seminars in immunopathology · 2009Review
- Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy.Mediators of inflammation · 2009Article
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Authors and funding
3 authors.
Funding
Abstract
In nearly every multifactorial human disease, there are three periods that characterize our understanding and definition. First, there is a period in which there is rapid accumulation of descriptive data. Second, there is a longer and slower period as information is obtained that redefines and expands basic and clinical knowledge that lacks the final and important area of understanding aetiology and therapeutic intervention. Third, which is much less common for most diseases, is the vigorous definition of pathobiology and treatment. These phases are well illustrated by our current understanding of primary biliary cirrhosis (PBC). The term PBC was first used nearly 60 years ago and for the first 40 or so years, the primary research efforts were directed at clinical definitions and pathology. Subsequently, with the advent of molecular biology, there began a rigorous dissection of the immune response and, in particular, a better understanding of anti-mitochondrial antibodies. These efforts have greatly helped in our understanding of not only the effector mechanisms of disease, but also the uniqueness of the primary target tissue, biliary epithelium. However, this research has still not led to successful translation for specific therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.