ArticleBiomaterials2008
Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering.
Article in Biomaterials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Fibrin as a Versatile Fibrous Biopolymer.Sub-cellular biochemistry · 2026Review
- Shape-fit 3D printed mineralized membrane for guided bone regeneration in long bone defects.Journal of nanobiotechnology · 2025Article
- A smart thermoresponsive macroporous 4D structure by 4D printing of Pickering-high internal phase emulsions stabilized by plasma-functionalized starch nanomaterials for a possible delivery system.Current research in food science · 2024Article
- Discussing the final size and shape of the reconstructed tissues in tissue engineering.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2023Review
- The Clinical Use of Osteobiologic and Metallic Biomaterials in Orthopedic Surgery: The Present and the Future.Materials (Basel, Switzerland) · 2023Review
- Advances in Fibrin-Based Materials in Wound Repair: A Review.Molecules (Basel, Switzerland) · 2022Review
- Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats.Veterinary world · 2021Article
- Biomaterials for Three-Dimensional Cell Culture: From Applications in Oncology to Nanotechnology.Nanomaterials (Basel, Switzerland) · 2021Review
- Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs.Frontiers in bioengineering and biotechnology · 2021Article
- Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.Biomedical materials (Bristol, England) · 2020Article
- A novel suprachoroidal microinvasive glaucoma implant: in vivo biocompatibility and biointegration.BMC biomedical engineering · 2020Article
- Current advances for bone regeneration based on tissue engineering strategies.Frontiers of medicine · 2019Review
- Development of an Injectable Nitric Oxide Releasing Poly(ethylene) Glycol-Fibrin Adhesive Hydrogel.ACS biomaterials science & engineering · 2019Article
- Spatiotemporally-controlled transgene expression in hydroxyapatite-fibrin composite scaffolds using high intensity focused ultrasound.Biomaterials · 2019Article
- Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain.Translational stroke research · 2019Review
- Effect of age on biomaterial-mediated in situ bone tissue regeneration.Acta biomaterialia · 2018Article
- Inverse Opal Scaffolds and Their Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2017Review
- A review of fibrin and fibrin composites for bone tissue engineering.International journal of nanomedicine · 2017Review
- Biofabrication and Bone Tissue Regeneration: Cell Source, Approaches, and Challenges.Frontiers in bioengineering and biotechnology · 2017Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The fibrotic response of the body to synthetic polymers limits their success in tissue engineering and other applications. Though porous polymers have demonstrated improved healing, difficulty in controlling their pore sizes and pore interconnections has clouded the understanding of this phenomenon. In this study, a novel method to fabricate natural polymer/calcium phosphate composite scaffolds with tightly controllable pore size, pore interconnection, and calcium phosphate deposition was developed. Microporous, nanofibrous fibrin scaffolds were fabricated using sphere-templating methods. Composite scaffolds were created by solution deposition of calcium phosphate on fibrin surfaces or by direct incorporation of nanocrystalline hydroxyapatite (nHA). The SEM results showed that fibrin scaffolds exhibited a highly porous and interconnected structure. Osteoblast-like cells, obtained from murine calvaria, attached, spread and showed a polygonal morphology on the surface of the biomaterial. Multiple cell layers and fibrillar matrix deposition were observed. Moreover, cells seeded on mineralized fibrin scaffolds exhibited significantly higher alkaline phosphatase activity as well as osteoblast marker gene expression compared to fibrin scaffolds and nHA incorporated fibrin scaffolds (0.25 and 0.5g). All types of scaffolds were degraded both in vitro and in vivo. Furthermore, these scaffolds promoted bone formation in a mouse calvarial defect model and the bone formation was enhanced by addition of rhBMP-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.