ArticleMetabolism: clinical and experimental2008
Proteomic analysis of fructose-induced fatty liver in hamsters.
Article in Metabolism: clinical and experimental, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis.Iranian biomedical journal · 2023Pooled it
- Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials.European journal of clinical nutrition · 2014Pooled it
- The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A Proteomics-based Analysis.Antioxidants (Basel, Switzerland) · 2020Article
- Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.Cellular and molecular life sciences : CMLS · 2020Review
- Differential Proteomic Analysis of Gender-dependent Hepatic Tumorigenesis in Hras12V Transgenic Mice.Molecular & cellular proteomics : MCP · 2017Article
- APOC3 Protein Is Not a Predisposing Factor for Fat-induced Nonalcoholic Fatty Liver Disease in Mice.The Journal of biological chemistry · 2017Article
- Bioactive Nutrients and Nutrigenomics in Age-Related Diseases.Molecules (Basel, Switzerland) · 2017Review
- Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease.Nature communications · 2016Article
- Nutritional systems biology of type 2 diabetes.Genes & nutrition · 2015Article
- Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research.Progress in lipid research · 2015Review
- Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice.Frontiers in endocrinology · 2014Article
- ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.The Journal of biological chemistry · 2013Article
- Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase?Journal of translational medicine · 2012Article
- High Fat Diet-Induced Changes in Hepatic Protein Abundance in Mice.Journal of proteomics & bioinformatics · 2012Article
- Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease.The Journal of nutritional biochemistry · 2011Article
- FoxO1 links hepatic insulin action to endoplasmic reticulum stress.Endocrinology · 2010Article
- Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet.Molecular & cellular proteomics : MCP · 2010Article
- FoxO1 integrates insulin signaling to VLDL production.Cell cycle (Georgetown, Tex.) · 2008Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
High fructose consumption is associated with the development of fatty liver and dyslipidemia with poorly understood mechanisms. We used a matrix-assisted laser desorption/ionization-based proteomics approach to define the molecular events that link high fructose consumption to fatty liver in hamsters. Hamsters fed high-fructose diet for 8 weeks, as opposed to regular-chow-fed controls, developed hyperinsulinemia and hyperlipidemia. High-fructose-fed hamsters exhibited fat accumulation in liver. Hamsters were killed, and liver tissues were subjected to matrix-assisted laser desorption/ionization-based proteomics. This approach identified a number of proteins whose expression levels were altered by >2-fold in response to high fructose feeding. These proteins fall into 5 different categories including (1) functions in fatty acid metabolism such as fatty acid binding protein and carbamoyl-phosphate synthase; (2) proteins in cholesterol and triglyceride metabolism such as apolipoprotein A-1 and protein disulfide isomerase; (3) molecular chaperones such as GroEL, peroxiredoxin 2, and heat shock protein 70, whose functions are important for protein folding and antioxidation; (4) enzymes in fructose catabolism such as fructose-1,6-bisphosphatase and glycerol kinase; and (5) proteins with housekeeping functions such as albumin. These data provide insight into the molecular basis linking fructose-induced metabolic shift to the development of metabolic syndrome characterized by hepatic steatosis and dyslipidemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.