ArticleBiochemical pharmacology2008
Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Article in Biochemical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 125 citations in OpenAlex.
- Article
- Localization and Aggregation of Honokiol in the Lipid Membrane.Antioxidants (Basel, Switzerland) · 2024Article
- Honokiol protects against diabetic retinal microvascular injury via sirtuin 3-mediated mitochondrial fusion.Frontiers in pharmacology · 2024Article
- Response Surface Methodology in Optimising the Extraction of Polyphenolic Antioxidants from Flower Buds ofMolecules (Basel, Switzerland) · 2023Article
- Honokiol and Alpha-Mangostin Inhibit Mayaro Virus Replication through Different Mechanisms.Molecules (Basel, Switzerland) · 2022Article
- The application prospects of honokiol in dermatology.Dermatologic therapy · 2022Review
- Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis.Pharmacology research & perspectives · 2022Article
- Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes.International journal of molecular sciences · 2022Article
- Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer's Disease.Oxidative medicine and cellular longevity · 2022Review
- Oxidation and Reduction Dual-Responsive Polymeric Prodrug Micelles Co-delivery Precisely Prescribed Paclitaxel and Honokiol for Laryngeal Carcinoma Combination Therapy.Frontiers in pharmacology · 2022Article
- Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells.Frontiers in pharmacology · 2022Article
- Alzheimer's disease treatment: The share of herbal medicines.Iranian journal of basic medical sciences · 2021Review
- Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol.Antioxidants (Basel, Switzerland) · 2020Article
- Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy.Cells · 2020Review
- Synthesis, characterization andAsian journal of pharmaceutical sciences · 2019Article
- Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis.Antioxidants (Basel, Switzerland) · 2019Article
- Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model.Molecules (Basel, Switzerland) · 2019Article
- Effect of feeding Chinese herb medicine ageratum-liquid on intestinal bacterial translocations induced by H9N2 AIV in mice.Virology journal · 2019Article
- Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo.Molecules (Basel, Switzerland) · 2018Article
- Synthesis of magnolol and honokiol derivatives and their effect against hepatocarcinoma cells.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Honokiol, a compound extracted from Magnolia officinalis, has antitumor and antiangiogenic properties in several tumor models in vivo. Among the downstream pathways inhibited by honokiol is nuclear factor kappa beta (NFkappabeta). A prime physiologic stimulus of NFkappabeta is reactive oxygen species. The chemical structure of honokiol suggests that it may be an effective scavenger of reactive oxygen species. In this work, we have studied the reactions of honokiol with superoxide and peroxyl radicals in cell-free and cellular systems using electron spin resonance (ESR) and high-performance liquid chromatography (HPLC) techniques. Honokiol efficiently scavenged superoxide radicals in xanthine oxidase and cytochrome P-450 cell-free systems with the rate constant 3.2x10(5)M(-1)s(-1), which is similar to reactivity of ascorbic acid but 20-times higher than reactivity of vitamin E analog trolox. Honokiol potently scavenged intracellular superoxide within melanoma cells. In addition, honokiol scavenged peroxyl radicals generated by 2,2'-azo-bis(2-amidinopropane hydrochloride) (AAPH). The rate constant of the reaction of honokiol with peroxyl radicals (1.4x10(6)M(-1)s(-1)) was calculated from the competition with spin trap 5-(ethoxycarbonyl)-5-methyl-1-pyrroline N-oxide (EMPO), and was found close to reactivity of trolox (2.5x10(6)M(-1)s(-1)). Therefore, honokiol is an effective scavenger of both superoxide and peroxyl radicals, which may be important for physiological activity of honokiol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.