ArticleGastroenterology2008
Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.
Article in Gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
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- PET/CT imaging detects intestinal inflammation in a mouse model of doxorubicin-induced mucositis.Frontiers in oncology · 2022Article
- Molecular Imaging of Inflammatory Disease.Biomedicines · 2021Review
- Evaluation of Anti-Colitis Effect of KM1608 and Biodistribution of Dehydrocostus Lactone in Mice Using Bioimaging Analysis.Plants (Basel, Switzerland) · 2020Article
- Aronia Berry Supplementation Mitigates Inflammation in T Cell Transfer-Induced Colitis by Decreasing Oxidative Stress.Nutrients · 2019Article
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- Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Contrast-Enhanced µCT for Visualizing and Evaluating Murine Intestinal Inflammation.Theranostics · 2018Article
- Imaging Radiation-Induced Gastrointestinal, Bone Marrow Injury and Recovery Kinetics Using 18F-FDG PET.PloS one · 2017Article
- Diagnostic imaging advances in murine models of colitis.World journal of gastroenterology · 2016Review
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- UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.The Journal of clinical investigation · 2015Article
- Rational development of radiopharmaceuticals for HIV-1.Nuclear medicine and biology · 2014Review
- FDG PET/CT in Crohn's disease: correlation of quantitative FDG PET/CT parameters with clinical and endoscopic surrogate markers of disease activity.European journal of nuclear medicine and molecular imaging · 2014Article
- Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.PloS one · 2014Article
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- Nuclear medicine imaging of infection in cancer patients (with emphasis on FDG-PET).The oncologist · 2011Article
- Advances in imaging of animal models of Chagas disease.Advances in parasitology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aims2-Deoxy-2-[(18)F]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET), a measure of glucose transporter activity, has been used to detect mucosal inflammation. However, there is limited understanding of the biologic basis of mucosal FDG uptake.
methodsA contrast-based computed tomographic isocontour method was developed to identify intestinal anatomic regions, and FDG uptake was integrated over these regions to achieve reproducible quantification during longitudinal assessment of individual mice. Intestinal FDG uptake was compared with histologic scores and with glucose transporter 1 levels in mucosal immune cells by flow cytometry.
resultsIntestinal FDG uptake quantitatively correlated with disease activity in mild (C3H/HeJ.IL-10(-/-)) and severe (129.Galphai2(-/-), CD4(+) CD45RB(high), and Galphai2(-/-) CD3(+) transfer) murine colitis models at all time points examined (P < .05) and was sufficiently sensitive to detect preclinical inflammation. FDG uptake was correlated by flow cytometric detection of glucose transporter 1 levels in mucosal CD4(+) T lymphocyte but not other intestinal immune cell types. CD4(+) T-cell transfer in vivo confirmed that mucosal FDG uptake was associated with the activated but not quiescent state. When intestinal inflammation was increased by treatment with piroxicam and decreased with anti-TL1A treatment, FDG uptake was correspondingly altered.
conclusionsThis study clarifies the cellular basis of FDG signal in intestinal inflammation and introduces computed tomographic isocontour analysis of FDG-PET imaging for standardized quantitation of immune colitis.
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