ArticleBiological psychiatry2008
An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.
Article in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.Biological psychiatry · 2011Pooled it
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- The bradykinin system in stress and anxiety in humans and mice.Scientific reports · 2019Article
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- OCDB: a database collecting genes, miRNAs and drugs for obsessive-compulsive disorder.Database : the journal of biological databases and curation · 2015Article
- Heterogeneity and individuality: microRNAs in mental disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Nature, nurture and epigenetics.Molecular and cellular endocrinology · 2014Review
- High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice.Genetics · 2014Article
- Controlling complexity: the clinical relevance of mouse complex genetics.European journal of human genetics : EJHG · 2013Review
- Anxiety genetics - findings from cross-species genome-wide approaches.Biology of mood & anxiety disorders · 2013Article
- Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Big effects of small RNAs: a review of microRNAs in anxiety.Molecular neurobiology · 2013Review
- Article
- Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms.Translational psychiatry · 2011Article
- Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.Translational psychiatry · 2011Article
- Advances in molecular genetics of panic disorder.Molecular psychiatry · 2010Review
- Article
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundHuman anxiety disorders are complex diseases with largely unknown etiology. We have taken a cross-species approach to identify genes that regulate anxiety-like behavior with inbred mouse strains that differ in their innate anxiety levels as a model. We previously identified 17 genes with expression levels that correlate with anxiety behavior across the studied strains. In the present study, we tested their 13 known human homologues as candidate genes for human anxiety disorders with a genetic association study.
methodsWe describe an anxiety disorder study sample derived from a Finnish population-based cohort and consisting of 321 patients and 653 carefully matched control subjects, all interviewed to obtain DSM-IV diagnoses. We genotyped altogether 208 single nucleotide polymorphisms (SNPs) (all non-synonymous SNPs, SNPs that alter potential microRNA binding sites, and gap-filling SNPs selected on the basis of HapMap information) from the investigated anxiety candidate genes.
resultsSpecific alleles and haplotypes of six of the examined genes revealed some evidence for association (p < or = .01). The most significant evidence for association with different anxiety disorder subtypes were: p = .0009 with ALAD (delta-aminolevulinate dehydratase) in social phobia, p = .009 with DYNLL2 (dynein light chain 2) in generalized anxiety disorder, and p = .004 with PSAP (prosaposin) in panic disorder.
conclusionsOur findings suggest that variants in these genes might predispose to specific human anxiety disorders. These results illustrate the potential utility of cross-species approaches in identification of candidate genes for psychiatric disorders.
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